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- 2015

补肾壮阳胶囊对精神分裂症模型大鼠认知行为的影响 Effects of Warm-Supplementing Kidney Yang Capsules on Cognitive Behavior in Schizophrenia's Model Rats

秦丽,陈振华,王高华,郭鑫,陈盛,韩娇

Keywords: 补肾壮阳胶囊,精神分裂症,MK801,认知

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Abstract:

目的:探讨补肾壮阳胶囊(WSKY)对MK801所致精神分裂症模型大鼠的认知行为影响。方法:将32只雄性SD大鼠随机分为4组:对照组(生理盐水灌胃+生理盐水腹腔注射),模型组(生理盐水灌胃+MK801腹腔注射),低剂量组[0.655g/(kg·d)WSKY灌胃+MK801腹腔注射],高剂量组[3.275g/(kg·d)WSKY灌胃+MK801腹腔注射]。WSKY预处理2周后腹腔注射MK801构建精神分裂症模型,建立模型后立即进行Morris水迷宫及旷场实验。结果:旷场实验:各组大鼠自发活动总路程无明显差异;Morris水迷宫:与对照组相比,模型组逃避潜伏时间显著延长(P<0.05),原平台象限停留时间及穿越次数显著减少(P<0.05);经WSKY干预2周的高剂量组逃避潜伏时间、原平台象限停留时间及穿越次数,与对照组比较无显著差异,与模型组及低剂量组相比均有显著差异(P<0.05)。结论:补肾壮阳胶囊能改善MK801所致谷氨酸能低下精神分裂症模型大鼠的认知行为

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