Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].Cancer J Clin,2015,65(2):87-108.
[2]
Derynck R,Akhurst RJ.Differentiation plasticity regulated by TGF-beta family proteins in development and disease[J].Nat Cell Biol,2007,9(9):1 000-1 004.
[3]
Guasch G,Schober M,Pasolli HA,et al.Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia[J].Cancer Cell,2007,12(4):313-327.
[4]
French D,Belleudi F,Mauro MV,et al.Expression of HPV16 E5 down-modulates the TGFbeta signaling pathway[J].Mol Cancer,2013,12:38.
[5]
Nagaraj NS,Datta PK.Targeting the transforming growth factor-beta signaling pathway in human cancer[J].Expert Opin Investig Drugs,2010,19(1):77-91.
[6]
Alcock RA,Dey S,Chendil D,et al.Farnesyltransferase inhibitor(L-744,832)restores TGF-beta typeⅡreceptor expression and enhances radiation sensitivity in Kras mutant pancreatic cancer cell line MIA PaCa-2[J].Oncogene,2002,21(51):7 883-7 890.
[7]
Engle SJ,Ormsby I,Pawlowski S,et al.Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice[J].Cancer Res,2002,62(22):6 362-6 366.
[8]
Fukai Y,Fukuchi M,Masuda N,et al.Reduced expression of transforming growth factor-beta receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma[J].Int J Cancer,2003,104(2):161-166.
[9]
Yamamoto N,Imai J,Watanabe M,et al.Restoration of transforming growth factor-beta type II receptor reduces tumorigenicity in the human adrenocortical carcinoma SW-13cell line[J].Horm Metab Res,2006,38(3):159-166.
[10]
Lampropoulos P,Zizi-Sermpetzoglou A,Rizos S,et al.TGF-beta signalling in colon carcinogenesis[J].Cancer Lett,2012,314(1):1-7.
[11]
Drabsch Y,ten Dijke P.TGF-beta signalling and its role in cancer progression and metastasis[J].Cancer Metastasis Rev,2012,31(3-4):553-568.