OALib Journal期刊
前列地尔对行急诊冠状动脉介入治疗术后急性心肌梗死患者肾功能的影响 Effects of Alprostadil Injection on Renal Function in Patients with Acute Myocardial Infarction Who Accepted PCI
Keywords: 前列地尔 ,经皮冠状动脉介入治疗 ,急性心梗 ,血肌酐 ,中性粒细胞明胶酶相关脂质运载蛋白
Abstract:
目的:研究急性心肌梗死(心梗)患者,在接受急诊经皮冠状动脉介入治疗(PCI)术前以及术后给予前列地尔治疗,观察患者尿素氮、血肌酐以及血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平的变化。方法:收集2011-2013年急性ST段抬高型心梗患者共60例,随机分为治疗组和对照组,两组在行PCI前均给予阿司匹林300mg和氯吡格雷600mg口服。治疗组在PCI前加用前列地尔10μg静脉推注。PCI术后两组均给予常规治疗,治疗组加用前列地尔10μg静脉推注,每天1次,连续5d。分析两组术前,术后6,24,72h尿素氮、血肌酐以及NGAL的变化。结果:术前两组的尿素氮、血肌酐以及NGAL水平没有明显差异(P>0.05)。术后6h,两组NGAL水平有所上升,对照组术后24,72h各指标均升高,差异有统计学意义,治疗组术后24h各指标有一定程度升高,但72h各指标与术前比较,差异无统计学意义。结论:使用前列地尔注射液对行急诊PCI术的急性心梗患者的肾功能有一定保护作用
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