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-  2017 

血清sCysC和β_2-MG的检测在阻塞性睡眠呼吸暂停低通气综合征患者肾功能损害早期发现中的意义 Detection of Serum Cystatin C and Beta2-Microglobulin Levels for Early Diagnosis of Renal Damage in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Keywords: 阻塞性睡眠呼吸暂停低通气综合征,β2微球蛋白,半胱氨酸蛋白酶抑制剂C,肾功能早期损害

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Abstract:

目的:探讨血清半胱氨酸蛋白酶抑制剂C(sCys C)及β_2微球蛋白(β_2-MG)用于检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者肾损伤的临床意义。方法:随机选取OSAHS患者91例作为OSAHS组,健康成年人39例作为对照组。采用肌氨酸氧化酶法和谷氨酸脱氢酶法分别对血清尿素氮(BUN)、血清肌酐(Scr)进行检测。血清Cys C及β_2-MG采用免疫比浊法进行检测。结果:血清BUN、Scr在对照组和OSAHS各组间差异无统计学意义(P>0.05)。血清Cys C、β_2-MG在OSAHS组和对照组差异有统计学意义(P<0.01),血清Cys C、β_2-MG在OSAHS各水平组间差异有统计学意义(P<0.01)。结论:OSAHS早期可能引起肾功能隐匿性损伤,血清β_2-MG,sCys C的变化早于BUN、SCr水平的变化,提示血清Cys C、β_2-MG有望作为较早反映OSAHS早期肾功能损害的灵敏指标

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