全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2016 

甲状腺癌分子诊断技术的研究进展 Research Progress of Molecular Diagnostic Techniques of Thyroid Cancer

Keywords: 甲状腺癌,分子诊断,基因突变,BRAF

Full-Text   Cite this paper   Add to My Lib

Abstract:

近年来,甲状腺癌发病率呈上升趋势,尤其在女性中,是最常见的内分泌恶性肿瘤之一。大量关于甲状腺癌的分子生物学变异被发现和定义,许多分子标记物能为甲状腺癌的风险评估提供依据,并具有优化手术治疗的潜能,为甲状腺癌患者提供更好的预后管理。如甲状腺癌相关基因BRAF突变的研究最为广泛,另外许多研究也对RAS,RET/PTC,和PAX8/PPARγ等基因的诊断价值进行了充分的评估。数据显示,这些标记物具有重要的诊断价值,有利于肿瘤的诊断以及作为潜在的治疗靶标。这篇综述讨论了甲状腺癌中最常见的分子遗传学变异及其临床意义,并评估了其诊断和预后的应用价值

References

[1]  Pita JM,Figueiredo IF,Moura MM,et al.Cell cycle deregulation and TP53and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas[J].J Clin Endocrinol Metab,2014,99(3):E497-E507.
[2]  Park JY,Kim WY,Hwang TS,et al.BRAF and RAS mutations in follicular variants of papillary thyroid carcinoma[J].Endocr Pathol,2013,24(2):69-76.
[3]  Cantwell ER,O’Leary JJ,Sheils OM,et al.BRAFV600E:implications for carcinogenesis and molecular therapy[J].Mol Cancer Ther,2011,10(3):385-394.
[4]  Marotta V,Guerra A,Sapio M,et al.RET/PTC rearrangement in benign and malignant thyroid diseases:a clinical standpoint[J].Eur J Endocrinol,2011,165:499-507.
[5]  Nikiforov YE.Molecular analysis of thyroid tumors[J].Mod Pathol,2011,24:S34-S43.
[6]  Elisei R,Viola D,Torregrossa L,et al.The BRAFV600E mutation is an independent,poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma:single-Institution results from a large cohort study[J].J Clin Endocrinol Metab,2012,97(12):4 390-4 398.
[7]  Hershman JM.Mutations of the RAS oncogene are found in follicular variant papillary thyroid carcinoma[J].Clin Thyroidol,2013,25:170-171.
[8]  Martina R,Mattia B,Federico T,et al.Relevance of BRAFV600Emutation testing versus RAS point mutations and RET/PTC rearrangements evaluation in the diagnosis of thyroid cancer[J].Thyroid,2015,25(2):221-228.
[9]  Armstrong MJ,Yang H,Ohori NP,et al.PAX8/PPARγrearrangement in thyroid nodules predicts follicular-pattern carcinomas,in particular the encapsulated follicular variant of papillary carcinoma[J].Thyroid,2014,24(9):1 369-1 374.
[10]  Santoro M,Carlomagno F.Central Role of RET in Thyroid Cancer[J].Cold Spring Harb Perspect Biol,2013,5(12):a009233
[11]  Scollo C,Russo M,De Gregorio L,et al.A novel RET gene mutation in a patient with apparently sporadic pheochromocytoma[J].Endocr J,2015,[Epub ahead of print].
[12]  American Thyroid Association Guidelines Task Force,Kloos RT,Eng C,et al.Medullary thyroid cancer:management guidelines of the American Thyroid Association[J].Thyroid,2009,19:565-612.
[13]  Guerra A,Zeppa P,Bifulco M,et al.Concomitant BRAF V600E Mutation and RET/PTC Rearrangement Is a Frequent Occurrence in Papillary Thyroid Carcinoma[J].Thyroid.2014,24(2):254-259.
[14]  Sozopoulos E,Litsiou H,Voutsinas G,et al.Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece[J].Endocr Pathol,2010,21(2):90-100.
[15]  Chiosea S,Nikiforova M,Zuo H,et al.A novel complex BRAF mutation detected in a solid variant of papillary thyroid carcinoma[J].Endocr Pathol,2009,20:122-126.
[16]  Soares P1,Lima J,Preto A,et al.Genetic Alterations in Poorly Differentiated and Undifferentiated Thyroid Carcinomas[J].Curr Genomics,2011,12(8):609-617.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133