组蛋白去乙酰化酶抑制剂介导的Akt/Gsk3β通路激活在糖尿病大鼠心肌缺血再灌注损伤中的保护作用 Protection Effect of Histones Deacetylases Inhibitor on Ischemia/Reperfusion Induced Myocardium Injury in Diabetic Rats
Li H,Liu Z,Wang J,et al.Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1diabetes in rats[J].Cardiovasc Diabetol,2013,12:133.
[2]
Williams SM,Golden-Mason L,Ferguson BS,et al.Class I HDACs regulate angiotensinⅡ-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes[J].J Mol Cell Cardiol,2014,67:112-125.
[3]
Juhaszova M,Zorov DB,Kim SH,et al.Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore[J].J Clin Invest,2004,113(11):1 535-1 549.
[4]
Das S,Wong R,Rajapakse N,et al.Glycogen synthase kinase 3inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation[J].Circ Res,2008,103(9):983-991.
[5]
Wu Y,Xia ZY,Dou J,et al.Protective effect of ginsenoside Rb1against myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats[J].Mol Biol Rep,2011,38(7):4 327-4 335.
[6]
Liu M,Zhou B,Xia ZY,et al.Hyperglycemia-induced inhibition of DJ-1expression compromised the effectiveness of ischemic postconditioning cardioprotection in rats[J].Oxid Med Cell Longev,2013,2013:564902.
[7]
Kubli DA,Gustafsson AB.Mitochondria and mitophagy:the yin and yang of cell death control[J].Circ Res,2012,111(9):1 208-1 221.
[8]
Witt O,Deubzer HE,Milde T,et al.HDAC family:What are the cancer relevant targets[J]?Cancer Lett,2009,277(1):8-21.
[9]
Zhao TC,Cheng G,Zhang LX,et al.Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury[J].Cardiovasc Res,2007,76(3):473-481.
[10]
Shi H,Chen L,Wang H,et al.Synergistic induction of miR-126by hypoxia and HDAC inhibitors in cardiac myocytes[J].Biochem Biophys Res Commun,2013,430(2):827-832.
[11]
Zhai P,Sciarretta S,Galeotti J,et al.Differential roles of GSK-3beta during myocardial ischemia and ischemia/reperfusion[J].Circ Res,2011,109(5):502-511.