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-  2015 

点阵CO_2和脉冲染料激光联合治疗对兔耳增生性瘢痕的影响 Effects of Lattice CO_2 and Pulsed Dye Laser Combined Treatment on Hyperplasic Scar of Rabbit Ears

Keywords: 增生性瘢痕,点阵CO2激光,脉冲染料激光,胶原蛋白

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Abstract:

目的:探讨点阵CO2和脉冲染料激光联合照射对兔耳增生性瘢痕的影响。方法:采用32只雄性新西兰大白兔建立兔耳增生性瘢痕模型,随机分为4组,A组:点阵CO2激光治疗组;B组:脉冲染料595nm激光治疗组、C组:点阵CO2激光和脉冲染料595nm激光联合治疗组;D组:对照组。观察瘢痕生长情况,比较治疗前后瘢痕增生指数,免疫组织化学SP法检测瘢痕组织中胶原蛋白Ⅰ、Ⅲ的水平。结果:瘢痕厚度:A、B、C组在治疗后均较D组下降(P<0.05);瘢痕增生指数:与D组比较,A、B、C组均显著下降(P<0.05),与C组比较,A、B组均显著升高(P<0.05);胶原蛋白Ⅰ、Ⅲ水平:与D组比较,B、C组显著下降(P<0.05),A组胶原蛋白Ⅰ水平显著下降、胶原蛋白Ⅲ水平显著升高(P<0.05)。结论:点阵CO2激光和脉冲染料激光联合照射有利于兔耳增生性瘢痕的治疗,其机制与抑制胶原蛋白合成和改善胶原结构有关

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