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-  2015 

腹腔镜及开腹胆总管探查术对血清IL-6、IL-10和CRP影响的比较 Comparison of Serum IL-6,IL-10,and CRP Levels in Patients Undergoing Open and Laparoscopic Common Bile Duct Exploration

Keywords: 腹腔镜胆总管探查术,开腹胆总管探查术,细胞因子,C反应蛋白

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Abstract:

目的:为腹腔镜胆总管探查术是否具有微创优越性提供免疫学及炎症反应方面的客观依据。方法:选择40例有胆总管探查指征的患者,随机分为腹腔镜胆总管探查组(LCBDE)和开腹胆总管探查组(OCBDE)。于术前(T0)、术后即刻(T1)、术后24h(T2)、及术后48h(T3)检测血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞(WBC)计数及C反应蛋白(CRP)水平,并比较两组的多项临床指标。结果:两组术后各期IL-6、IL-10、WBC及CRP水平均发生显著变化。与OCBDE手术组相比,LCBDE手术组平均手术时间短(P<0.01)、术后镇痛用药率低(P<0.01)、术后发热天数少(P<0.05)、术后输液量少(P<0.01)、术后平均住院日短(P<0.01)。结论:腹腔镜手术对术后免疫功能影响较小,有利于病人恢复

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