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-  2015 

同源异型盒基因HOXB7在乳腺癌组织中的表达及其意义 Expression of Homeobox B7(HOXB7)and Its Clinical Significance in Breast Cancers

Keywords: 乳腺癌,HOXB7,Western blotting,RT-PCR

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Abstract:

目的:探讨同源异型盒基因B7(HOXB7)在乳腺癌组织中的表达及其临床意义。方法:分别应用Western blotting和RT-PCR方法检测48例乳腺癌组织、20例乳腺纤维腺瘤组织、20例正常乳腺组织中HOXB7蛋白和HOXB7mRNA的表达水平,并分析HOXB7mRNA的表达量与乳腺癌患者年龄、临床分期以及病理分级、淋巴结转移等特征的关系。结果:与乳腺纤维腺瘤组织和正常乳腺组织相比,HOXB7蛋白及HOXB7mRNA在乳腺癌组织中的表达水平均显著增高(P<0.05),且HOXB7蛋白及HOXB7mRNA在乳腺纤维腺瘤组织中的表达水平显著高于正常乳腺组织(P<0.05)。临床分期Ⅲ期组、浸润性乳腺癌病理分级Ⅲ级组的乳腺癌病例中HOXB7mRNA的表达水平均显著高于Ⅰ期组(P<0.05),淋巴结转移阳性组HOXB7mRNA的表达明显高于淋巴结转移阴性者(P<0.05)。结论:HOXB7在乳腺癌组织中高表达,且与乳腺癌恶性程度、分期、分级密切相关

References

[1]  Shah N,Sukumar S.The Hox genes and their roles in oncogenesis[J].Nat Rev Cancer,2010,10(5):361-371.
[2]  De Souza Setubal Destro MF,Bitu CC,Zecchin KG,et al.Overexpression of HOXB7homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis[J].Int J Oncol,2010,36(1):141-149.
[3]  Nguyen Kovochich A,Arensman M,Lay AR,et al.HOXB7promotes invasion and predicts survival in pancreatic adenocarcinoma[J].Cancer,2013,119(3):529-539.
[4]  Liao WT,Jiang D,Yuan J,et al.HOXB7as a prognostic factor and mediator of colorectal cancer progression[J].Clin Cancer Res,2011,17(11):3 569-3 578.
[5]  De Sibio MT,de Oliveira M,Moretto FC,et al.Triiodothyronine and breast cancer[J].World J Clin Oncol,2014,5(3):503-508.
[6]  Cantile M,Pettinato G,Procino A,et al.In vivo expression of the whole HOX gene network in human breast cancer[J].Eur J Cancer,2003,39(2):257-264.
[7]  Cheng W,Liu J,Yoshida H,et al.Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract[J].Nat Med,2005,11(5):531-537.
[8]  Yuan W,Zhang X,Xu Y,et al.Role of HOXB7in regulation of progression and metastasis of human lung adenocarcinoma[J].Mol Carcinog,2014,53(1):49-57.
[9]  Cantile M,Scognamiglio G,La Sala L,et al.Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers[J].Int J Mol Sci,2013,14(11):21 727-21 740.
[10]  Shah N,Jin K,Cruz LA,et al.HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERαand inducing IL-6expression[J].Cancer Res,2013,73(17):5 449-5 458.

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