徐阳光.分枝杆菌降解植物甾醇侧链过程基础研究[D].杭州:浙江大学,2014.XU Y G.Side-chain Cleavage of Phvtosterols by Mycobacterium sp MB 3683[D].Hangzhou:Zhejiang University,2014(Ch).
[2]
车成彬,刘景春,吴宝华.大豆甾醇侧链的生物降解[J].哈尔滨理工大学学报,2002,7(1):93-95.DOI:10.3969/j.issn.1007-2683.2002.01.028.CHE C B,LIU J C,WU B H.Microbial transformation of soybean sterol[J].Journal of Harbin University of Science and Technology,2002,7(1):93-95.DOI:10.3969/j.issn.1007-2683.2002.01.028(Ch).
[3]
姚抗.分枝杆菌甾醇代谢机制的解析以及其代谢工程改造应用于制备重要甾药中间体的研究[D].上海:华东理工大学,2014.YAO K.Investigation into the Molecular Mechanism of Microbial Sterol Degradation and Its Metabolic Engineering for the Production of Steroid Pharmaceutical[D].Shanghai:East China University of Science and Technology,2014(Ch).
[4]
WEI W,FAN S Y,WANG F Q,et al.Accumulation of androstadiene-dione by overexpression of heterologous 3-ketosteroid-Δ1-dehydrogenase in Mycobacterium neoaurum NwIB-01[M].World Journal of Microbiology&Biotechnology,2014,30:1947-1954.DOI:10.1007/s11274-014-1614-3.
[5]
黄培堂.分子克隆实验指南精编版[M].北京:化学工业出版社,2008.HUANG P T.The Condensed Protocols from Molecular cloning:A Laboratory Manual[M].Beijing:Chemical Industry Press,2008(Ch).
[6]
杨英,姜绍通,赵俊平,等.微生物转化植物甾醇为雄烯二酮检测方法的建立[J].食品与发酵工业,2008,11:152-155.DOI:10.13995/j.cnki.11-1802/ts.2008.11.003.YANG Y,JIANG S T,ZHAO J P,et al.Method for detecting the transformation of phytosterol to androst-4-ene-3,17-dione with microorganism[J].Food and Fermentation Industries,2008,11:152-155.DOI:10.13995/j.cnki.11-1802/ts.2008.11.003(Ch).
[7]
YAO K,XU L Q,WANG F Q,et al.Characterization and engineering of 3-ketosteroid-Δ1-dehydrogenase and 3-ketosteroid-9α-hydroxylase in Mycobacterium neoaurum ATCC 25795to produce 9α-hydroxy-4-androstene-3,17-dione through the catabolism of sterols[J].Metabolic Engineering,2014,24:181-191.DOI:10.1016/j.ymben.2014.05.005.
[8]
ARIMA K,NAGASAWA M,BAE M.Microbial transformation of sterols.PartⅠ.Decomposition of cholesterol by microorganisms[J].Agricultural Biological Chemistry,1969,33:1636.DOI:10.1271/bbb1961.33.1636.
[9]
张小燕,阮晖,何国庆.微生物降解植物甾醇侧链生产雄甾烯二酮的研究进展[J].中国食品学报,2012,12(7):162-170.DOI:10.3969/j.issn.1009-7848.2012.07.024.ZHANG X Y,RUAN H,HE G Q.Advances in microbial transformation of phytosterols to androstenedione[J].Journal of Chinese Institute of Food Science and Technology,2012,12(7):162-170.DOI:10.3969/j.issn.1009-7848.2012.07.024(Ch).
[10]
韩冷.新金色分枝杆菌中AD转化为ADD关键酶KSDD的研究[D].无锡:江南大学,2010.HAN L.Study on the Key Enzyme KSDD in the Bioconversion of AD Into ADD in Mycobacterium Neoaurum[D].Wuxi:Jiangnan University,2010(Ch).
[11]
李玉,田琳,刘逸寒,等.微生物3-甾酮-Δ1-脱氢酶的研究进展[J].药物生物技术,2007,14(2):149-152.DOI:10.3969/j.issn.1005-8915.2007.02.017.LI Y,TIAN L,LIU Y H,et al.The research advances on 3-ketosteroid-Δ1-dehydrogenase of microorganism[J].Pharmaceutical Biotechnology,2007,14(2):149-152.DOI:10.3969/j.issn.1005-8915.2007.02.017(Ch).
[12]
刘学胜,贾全栋,张伟国.产丁二酸谷氨酸棒状杆菌基因缺失代谢工程菌株的构建[J].微生物学通报2013,40(5):739-748.LIU X S,JIA Q D,ZHANG W G.Construction a metabolic engineering strain to produce succinic acid from Corynebacterium glutamicum by gene deletion mutation[J].Microbiology,2013,40(5):739-748(Ch).
[13]
杨英.微生物转化植物甾醇制备甾体药物关键中间体研究[D].合肥:合肥工业大学,2009.YANG Y.Study on Bioconversion of Phytosteril into Steroid Medicine Intermediates by Mycobacter[D].Hefei:Hefei University of Technology,2009(Ch).
[14]
魏巍.Mycobacterium neoaurum NwIB-01降解甾醇母核关键酶3-甾酮-Δ1-脱氢酶和3-甾酮-9α-羟化酶基因的鉴定及其基因工程改造[D].上海:华东理工大学,2010.WEI W.Identifieation and Gene Modification of Key Genes about 3-Ketosteroid-Δ1-dehydrogenase and3-Ketosteroid-9α-Hydroxylase involved in steroid Nucleus Degradation in Mycobacterium neoaurum NwIB-01 and Strain Development via Genetic Manipulation[D].Shanghai:East China University of Science and Technology,2010(Ch).
[15]
XIE R L,SHEN Y B,WANG M,et al.Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum[J].Journal of Industrial Microbiology&Biotechnology,2015,42(4):507-513.DOI:10.1007/s10295-014-1577-2.
[16]
张成刚,王风清,魏东芝.分枝杆菌Mycobacterium Neoaurum NwIB-01 3-甾酮-Δ1-脱氢酶基因的克隆表达[J].化学与生物工程,2011,7:39-43.DOI:10.3969/j.issn.1672-5425.2011.07.009.ZHANG C G,WANG F Q,WEI D Z.The Clone and Expression of 3-Ketosteroid-Δ1-dehydrogenase from Mycobacterium Neoaurum NwIB-01[J].Chemistry&Bioengineering,2011,7:39-43.DOI:10.3969/j.issn.1672-5425.2011.07.009(Ch).
[17]
陈苗苗,林良才,魏东芝,等.烟曲霉Aspergillus Fumigatus 3-甾酮-Δ1-脱氢酶基因的克隆、异源表达和活性鉴定[J].化学与生物工程,2011,7:29-34.DOI:10.3969/j.issn.1672-5425.2011.07.007.CHEN M M,LIN L C,WEI D Z,et al.Cloning heterologous expression and activity identification of 3-ketosteroid-Δ1-dehydrogenase from Aspergillus Fumigatus[J].Chemistry&Bioengineering,2011,7:29-34.DOI:10.3969/j.issn.1672-5425.2011.07.007(Ch).
[18]
张裕卿,王东青.植物甾醇微生物转化制备甾体药物中间体的研究进展[J].微生物学通报,2006,33(2):142-146.DOI:10.3969/j.issn.0253-2654.2006.02.029.ZHANG Y Q,WANG D Q.Advances in microbial transformation of phytosterol into steroid medicine intermediates[J].Microbiology,2006,33(2):142-146.DOI:10.3969/j.issn.0253-2654.2006.02.029(Ch).
[19]
吴庆安,吴红卫,柏挺.植物油脚中植物甾醇作为甾体药物原料的发展前景[J].现代化工,2015(7):4-6.WU Q A,WU H W,BO T.Prospects of phytosterol from vegetable oil residue as raw materials for steroid drugs[J].Modern Chemical Engineering,2015(7):4-6(Ch).
[20]
WEI W,FAN S Y,WANG F Q,et al.A new steroid-transforming strain of Mycobacterium neoaurum and cloning of 3-ketosteroid 9a-hydroxylase in NwIB-01[J].Applied Biochemistry and Biotechnology,2010,162(5):1446-1456.DOI:10.1007/s12010-010-8919-y.
[21]
赵丽萍.分枝杆菌降解植物甾醇生产雄烯二酮的发酵研究[D].保定:河北农业大学,2008.ZHAO L P.Study on Fermentation of Degrading Phytosterol Into and Rostenone by Mycobacterium[D].Baoding:Hebei Agricultural University,2008(Ch).
[22]
张蓓娜.天然甾醇资源的利用——1.2-甲氧基雌二醇的合成2.从ADD合成高效皮质激素结构转化关键方法的探索和研究[D].上海:复旦大学,2006.ZHANG B N.The Utility of Natural Sterols Study—1.Synthesis of 2-methoxyestradiol 2.Study on Some Key Points for Converting ADD to Highly Active Glucocorticoids[D].Shanghai:Fudan University,2006(Ch).
[23]
张乐乐,张显,邵明龙,等.表达3-甾酮-Δ~1-脱氢酶降解植物甾醇合成雄甾-1,4-二烯-3,17-二酮[J].生物工程学报,2015,11:1589-1600.DOI:10.13345/j.cjb.140579.ZHANG L L,ZHANG X,SHAO M L,et al.Overexpressing 3-ketosteroid-Δ1-dehydrogenase for degrading phytosterols into androst-1,4-diene-3,17-dione[J].Chinese Journal of Biotechnology,2015,11:1589-1600.DOI:10.13345/j.cjb.140579(Ch).
