全脑缺血大鼠脑组织MiR210和stat3的表达与HIF-1α的相关性
Expressions of MiR210 and stat3 following global ischemia in rats and the potential relationship among MiR210, stat3 and HIF-1α

DOI: 10.6040/j.issn.1671-7554.0.2014.943

Keywords: MiR210,大鼠,信号转导和转录激活因子3,缺氧诱导因子-1α,全脑缺血,
Rat,MiR210,Signal transducer and activator of transcripation 3,Global ischemia,Hypoxia inducible factor-1α

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[1]	Lee JW, Bae SH, Jeong JW, et al. Hypoxia-inducible factor (HIF-1)α:its protein stability and biological functions[J]. Exp Mol Med, 2004, 36(1):1-12.
[2]	Bergeron M, Yu YA, Solway KE, et al. Induction of hypoxia-induced factor-1(HIF-1) and its target genes following focal ischemia in rat brain[J]. Eur J Neurosci, 1999, 11(12):4159-4170.
[3]	Kisseleva T, Bhattacharya S, Braunstein J, et al. Signaling through the JAK/STAT pathway, recent advances and future challenges[J]. Gene, 2002, 285(1-2):1-24.
[4]	Nechemia AY, Khamaisi M, Rosenberger C, et al. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription3 activation in response to hypoxic and non-hypoxic stimuli[J]. Clin Exp Pharmacol Physiol, 2013, 40(4):262-272.
[5]	Kulshreshtha R, Ferracin M, Wojcik SE, et al. A microRNA signature of hypoxia[J]. Mol Cell Biol, 2007, 27(5):1859-1867.
[6]	Huang X, Le QT, Giaccia AJ. MiR-210--micromanager of the hypoxia pathway[J]. Trends Mol Med, 2010, 16(5):230-237.
[7]	Chang KP, Lee HC, Huang SH, et al. MicroRNA signatures in ischemia-reperfusion injury[J]. Ann Plast Surg, 2012, 69(6):668-671.
[8]	Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion[J]. Stroke, 2008, 39(3):959-966.
[9]	Liu DZ, Tian Y, Ander BP, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures[J]. J Cereb Blood Flow metab, 2010, 30(1):92-101.
[10]	Zeng L, He X, Wang Y, et al. MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain[J]. Gene Ther, 2014, 21(1):37-43.
[11]	高法梁,娄远蕾,阮琼芳, 等.缺血性脑损伤大鼠MicroRNA-210的动态变化[J].实验与检验医学,2010, 28(3):230-232. GAO Faliang, LOU Yuanlei, RUAN Qiongfang, et al. Dynamic changes of miR-210 after brain stroke in rats[J]. Experimental and Laboratory Medicine, 2010, 28(3):230-232.
[12]	Kirino T, Tamura A, Sano K. Delayed Neuronal Death in the rat hippocampus following transient forebrain ischemia[J]. Acta Neuropathol, 1984, 64(2):139-147.
[13]	Pulsinelli WA, Brierley JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia[J]. Ann Neurol, 1982, 11(5):491-498.
[14]	Dziennis S, Alkayed NJ. Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration[J]. Rev Neurosci, 2008, 19(4-5):341-361.
[15]	Chan SY, Loscalzo J. MicroRNA-210:a unique and pleiotropic hypoxamir[J]. Cell Cycle, 2010, 9(6):1072-1083.
[16]	Zeng L, Liu J, Wang Y, et al. MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia[J]. Front Biosci, 2011, 3(4):1265-1272.
[17]	Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the unanesthetized rat[J]. Stroke, 1979, 10(3):267-272.
[18]	Schust J, Sperl B, Hollis A, et al. Stattic:a small-molecule inhibitor of STAT3 activation and dimerization[J]. Chem Biol, 2006, 13(11):1235-1242.
[19]	Suzuki S, Tanaka K, Nogawa S, et al. Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats[J]. Exp Neurol, 2001, 170(1):63-71.
[20]	Wen TC, Peng H, Hata R, et al. Induction of phosphorylated-stat3 following focal cerebral ischemia in mice[J]. Neurosci Letters, 2001, 303(3):153-156.
[21]	谢慧芳,徐如祥,魏继鹏. JAK2/STAT3信号转导通路在缺血性脑损伤中的作用机制的研究[J].中风与神经疾病杂志, 2008, 25(2):135-138. XIE Huifang, XU Ruxiang, WEI Jipeng, et al. The mechanism of JAK2/STAT3 signal pathway in ischemic brain injury in rats[J]. Apoplexy and Nervous Disease, 2008, 25(2):135-138.
[22]	Jung JE, Lee HG, Cho IH, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells[J]. FASEB, 2005, 19(10):1296-1298.
[23]	Satriotomo I, Bowen KK, Vemuganti R. JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia[J]. J Neurochem, 2006, 98(5):1353-1368.
[24]	Yadav A, Kalita A, Dhillon S, et al. JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3[J]. J Biol Chem, 2005, 280(36):31830-31840.

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