硫辛酸对帕金森病大鼠黑质线粒体的保护作用
Protection of thioctic acid in mitochondria in the rat model of Parkinsons disease

DOI: 10.6040/j.issn.1671-7554.0.2016.1225

Keywords: 硫辛酸,线粒体,6-羟基多巴胺,帕金森病,
6-Hydroxydopamine,Parkinsons disease,Thioctic acid,Mitochondria

Full-Text   Cite this paper   Add to My Lib

Abstract:

References

[1]	Kupsch A, Schmidt W, Gizatullina Z, et al. 6-Hydro-xydopamine impairs mitochondrial function in the rat model of Parkinsons disease: respirometric, histological, and behavioral analyses[J]. J Neural Transm(Vienna), 2014, 121(10): 1245-1257.
[2]	贾丛康, 杨新玲, 姜涛,等.6-羟基多巴胺所致帕金森病大鼠模型稳定性的研究[J].中国老年学杂志,2009,29(5): 521-524. JIA Congkang, YANG Xinling, JIANG Tao, et al. Study on the stability of establishment of Parkinsons disease(PD)model rats by injection 6-OHDA[J].Chinese Journal of Gerontology, 2009, 29(5): 521-524.
[3]	Dabbeni-Sala F, Di Santo S, Franceschini D, et al. Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity[J]. FASEB J, 2001, 15(1): 164-170.
[4]	Santos D, Esteves AR, Silva DF, et al. The impact of mitochondrial fusion and fission modulation in sporadic Parkinsons disease[J]. Mol Neurobiol, 2015, 52(1): 573-586.
[5]	Kalia LV, Lang AE. Parkinsons disease[J]. Lancet,2015,386(9996): 896-912.
[6]	Jalali-Nadoushan M, Roghani M. Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism[J]. Brain Res, 2013, 1505: 68-74.doi:10.1016/j.brainres.2013.01.054.
[7]	Li YH, He Q, Yu JZ, et al. Lipoic acid protects dopaminergic neurons in LPS-induced Parkinsons disease model[J].Metab Brain Dis, 2015, 30(5):1217-1226.
[8]	Charli A, Jin H, Anantharam V, et al. Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model[J]. Neurotoxicology, 2016, 53:302-313.
[9]	Bingol B, Tea JS, Phu L, et al. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy[J]. Nature, 2014, 510(7505): 370-375.
[10]	徐利, 张春林, 周波, 等. 硫辛酸对帕金森模型大鼠黑质内神经胶质细胞及多巴胺能神经元的影响[J]. 神经解剖学杂志,2015,31(1):59-64. XU Li, ZHANG Chunlin, ZHOU Bo, et al.The effect of lipoic acid on neuroglial cell and dopaminergic neurons in substantia nigra of Parkinsons disease model rats[J].Chinese Journal of Neuroanatomy, 2015, 31(1): 59-64.
[11]	Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis[J]. Nat Clin Pract Neurol, 2008, 4(11):600-609.
[12]	刘毅, 杨明会, 窦永起, 等.6-羟基多巴胺诱发帕金森病大鼠模型的制作和评价[J].解放军医学杂志,2007,32(11): 1160-1162. LIU Yi, YANG Minghui, DOU Yongqi, et al.Reproduction and evaluation of 6-OHDA-induced rat model of Parkinson's disease[J].Medical Journal of Chinese Peoples Liberation Army, 2007, 32(11): 1160-1162.
[13]	Thiele SL, Warre R, Nash JE. Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinsons disease[J]. J Vis Exp, 2012, 60: e3234. doi:10.3791/3234(2012).
[14]	候瑞民,彭国光.帕金森病的线粒体功能障碍与氧化应激[J].国际老年医学杂志,2015,36(3):133-135. HOU Ruimin, PENG Guoguang. Mitochondrial dysfunction and oxidative stress of Parkinsons disease[J].International Journal of Geriatrics, 2015, 36(3):133-135.
[15]	孟祥继, 庞琦, 丁锋, 等. 纹状体立体定向注射Taclo建立帕金森病大鼠模型[J].山东大学学报(医学版), 2014, 52(3): 16-18. MENG Xiangji, PANG Qi, DING Feng, et al. Establishment of PD rat model by injecting Taclo sterically and directionally into striatum[J]. Journal of Shandong University(Health Science), 2014, 52(3):16-18.
[16]	De Araujo DP, De Sousa CN, Araujo PV, et al. Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parkinsons disease induced by unilateral stereotaxic injection of 6-ohda in rat[J]. Evid Based Complement Alternat Med, 2013:571378. doi:10.1155/2013/571378.
[17]	Tieu K. A guide to neurotoxic animal models of Parkinsons disease[J]. Cold Spring Harb Perspect Med, 2011, 1(1): a009316.doi:10.1101/cshperspect.a009316.
[18]	Gautier CA, Kitada T, Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress[J]. Proc Natl Acad Sci U S A, 2008, 105(32):11364-11369.
[19]	Peng K, Yang L, Wang J. The interaction of mitochondrial biogenesis and fission/fusion mediated by PGC-1alpha regulates rotenone-induced dopaminergic neurotoxicity[J]. Mol Neurobiol, 2016, Jun7. [Epub ahead of print].doi:10.1007/s12035-016-9944-9.
[20]	Archer SL. Mitochondrial dynamics-mitochondrial fission and fusion in human diseases[J]. N Engl J Med, 2013, 369(23): 2236-2251.
[21]	Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress[J]. Science, 2012, 337(6098): 1062-1065.
[22]	曹海燕, 翟玉龙, 孙夏承, 等. 基于电镜和免疫组化的线粒体数目标志物评估肝癌的初步研究[J].现代生物医学进展, 2016, 16(14):2646-2650. CAO Haiyan, ZHAI Yulong, SUN Xiacheng, et al. Evaluation of hepatocellular carcinoma growth based on mitochondrial molecular marker using transmission electron microscope and immunohistochemistry[J]. Progress in Modern Biomedicine, 2016, 16(14):2646-2650.

Full-Text