IB期非小细胞肺癌Runx2、Ezrin表达与术后转移的相关性
Correlation between the expressions of Runx2 and Ezrin and postoperative metastasis in patients with stage IB non-small cell lung cancer

DOI: 10.6040/j.issn.1671-7554.0.2014.652

Keywords: 肿瘤转移,埃兹蛋白,非小细胞肺癌,Runt相关转录因子2,
Runt-related transcription factor 2,Ezrin,Non-small cell lung cancer,Neoplasm metastasis

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References

[1]	Ettinger DS, Akerley W, Borghaei H, et al. Non-small cell lung cancer, version 2.2013[J]. J Natl Compr Canc Netw, 2013, 11(6):645-653.
[2]	Hung JJ, Jeng WJ, Hsu WH, et al. Predictors of death, local recurrence, and distant metastasis in completely resected pathological stage-I nonsmall-cell lung cancer[J]. J Thorac Oncol, 2012, 7(7):1115-1123.
[3]	Selvamurugan N, Kwok S, Partridge NC. Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells[J]. J Biol Chem, 2004, 279(26):27764-27773.
[4]	Gautreau A, Poullet P, Louvard D, et al. Ezrin, a plasma membranemicrofilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway[J]. Proc Natl Acad Sci U S A, 1999, 96(13):7300-7305.
[5]	Jin T, Jin J, Li X, et al. Prognostic implications of ezrin and phosphorylated ezrin expression in non-small cell lung cancer[J]. BMC Cancer, 2014, 14:191.
[6]	Zhang XQ, Chen GP, Wu T, et al. Expression and clinical significance of ezrin in non-small cell lung cancer[J].Clin Lung Cancer, 2012, 13(3):196-204.
[7]	闵大六,沈赞,林峰,等. Runx2和Ezrin基因在骨瘤组织中的表达及其临床意义[J].中国癌症杂志, 2012, 22(9):685-689. MIN Daliu, SHEN Zan, LIN Feng, et al. Clinical signi fi cances of Runx2 and Ezrin expressions in osteosarcoma[J]. China Oncology, 2012, 22(9):685-689.
[8]	Chen W, Zheng R, Zhang S, et al. The incidences and mortalities of major cancers in China, 2009[J]. Chin J Cancer, 2013, 260(3):106-112.
[9]	Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions[J]. J Clin Invest, 2009, 119(6):1429-1437.
[10]	Jiang W, Chen X, Xi J, et al. Selective mediastinal lymphadenectomy without intraoperative frozen section examinations for clinical stage I non-small-cell lung cancer:retrospective study of 403 cases[J]. World J Surg, 2013, 37(2):392-397.
[11]	Sadikovic B, Thorner P, Chilton-MacNeill S, et al. Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy [J]. BMC Cancer, 2010, 10:202.
[12]	Onodera Y, Miki Y, Suzuki T, et al. Runx2 in human breast carcinoma:its potential roles in cancer progression[J]. Cancer Sci, 2010, 101(12):2670-2675.
[13]	Yun SJ, Yoon HY, Bae SC, et al. Transcriptional repression of RUNX2 is associated with aggressive clinicopathological outcomes, whereas nuclear location of the protein is related to metastasis in prostate cancer[J]. Prostate Cancer and Prostatic Dis, 2012, 15(4):369-373.
[14]	Pratap J, Imbalzano KM, Underwood JM, et al. Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure:implications for breast cancer progression[J].Cancer Res, 2009, 69(17):6807-6814.
[15]	Yang J, Zhao L, Tian W, et al. Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma[J]. BMC Med Genomics, 2013, 6:56.
[16]	Baniwal SK, Khalid O, Gabet Y, et al. Runx2 transcriptome of prostate cancer cells:insights into invasiveness and bone metastasis. [J]. Mol Cancer, 2010, 9:258.
[17]	Li H, Zhou RJ, Zhang GQ, et al. Clinical significance of RUNX2 expression in patients with nonsmall cell lung cancer:a 5-year follow-up study[J]. Tumour Biol, 2013, 34(3):1807-1812.
[18]	Hsu YL, Huang MS, Yang CJ, et al. Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway[J]. J Biol Chem, 2011, 286(43):37335-37346.
[19]	Pratap J, Javed A, Languino LR, et al. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion[J]. Mol Cell Biol, 2005, 25(19):8581-8591.
[20]	Rebillard A, Jouan-Lanhouet S, Jouan E, et al. Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells[J]. Eur J Cancer, 2010, 46(8):1445-1455.

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