超时间窗溶栓治疗对大鼠急性脑梗死后自由基活性和Caspase-3表达的影响
Effects of thrombolytic therapy with broadened therapeutic window on the free radical activity and the expression of Caspase-3 in a rat model of acute cerebral infarction

DOI: 10.6040/j.issn.1671-7554.0.2014.773

Keywords: 脑梗死,一氧化氮合酶,超时间窗,溶栓,Caspase-3,
Cerebral infarction,Nitric-oxide synthase,Caspase-3,Thrombolysis,Time window

Full-Text   Cite this paper   Add to My Lib

Abstract:

References

[1]	Gaur V, Aggarwal A, Kumar A. Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain[J]. Eur J Pharmacol, 2009, 616(1-3):147-154.
[2]	The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke[J]. N Engl J Med, 1995, 333(24):1581-1587.
[3]	林艳,刘金之,刘杰,等. 超时间窗溶栓治疗对急性脑梗死体积、微血管密度及黏附因子表达的影响[J]. 山东大学学报:医学版,2014,52(5): 20-24. LIN Yan, LIU Jinzhi, LIU Jie, et al. Effect of thrombolytic therapy with broadened therapeutic window on infarct volume, microvessel density and adherence factors in acute cerebral infarction[J]. Jounal of Shandong University: Health Sciences, 2014, 52(5):20-24.
[4]	Chauhan A, Sharma U, Jagannathan NR, et al. Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats[J]. Behav Brain Res, 2011, 225(2):603-609.
[5]	Donnan GA, Davis SM. IST-3: a major contribution to thrombolysis research[J]. Int J Stroke, 2012, 7(7):566-567.
[6]	Donnan GA, Davis SM. Stroke: Expanded indications for stroke thrombolysis—what next?[J]. Nat Rev Neurol, 2012, 8(9):482-483.
[7]	Choi-Kwon S, Park KA, Lee HJ, et al. Temporal changes in cerebral antioxidant enzyme activities after ischemia and reperfusion in a rat focal brain ischemia model: effect of dietary fish oil[J]. Brain Res Dev Brain Res, 2004, 152(1): 11-18.
[8]	Ogata T, Christensen S, Nagakane Y, et al. The effects of alteplase 3 to 6 hours after stroke in the EPITHET-DEFUSE combined dataset: post hoc case-control study[J]. Stroke, 2013, 44(1): 87-93.
[9]	Balami JS, Hadley G, Sutherland BA,et al. The exact science of stroke thrombolysis and the quiet art of patient selection[J]. Brain, 2013(pt12), 136:3528-3553.
[10]	Irmak MK, Fadillioglu E, Sogut S, et al. Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain[J]. Cell Biochem Funct, 2003, 21(3): 283-289.
[11]	He S, Yang J, Wu B, et al. Neuroprotective effect of parthenocissin A, a natural antioxidant and free radical scavenger, in focal cerebral ischemia of rats[J]. Phytother Res, 2010, 24(Suppl 1):S63-70.
[12]	Goto K, Ishige A, Sekiguchi K, et al. Effects of cycloheximide on delayed neuronal death in rat hippocampus[J]. Brain Res, 1990, 534(1-2):299-302.
[13]	Broughton BR, Reutens DC and Sobey CG. Apoptotic mechanisms after cerebral ischemia[J]. Stroke, 2009, 40(5):e331-339. doi:10.1161/STROKEAHA.531632.
[14]	Bai Q, Zhao Z, Sui H, et al. Comparison of fast MRI-based individual thrombolysis therapy for patients with superacute infarction[J]. J Stroke Cerebrovasc Dis, 2014, 23(4): e263-269. doi:10.1016/j.jstrokecerebrovasdis.2013.11.014.
[15]	Allen CL, Bayraktutan U. Oxidative stress and its role in the pathogenesis of ischaemic stroke[J]. Int J Stroke, 2009, 6(4):461-470.
[16]	Doyle KP, Simon RP, Stenzel-Poore MP. Mechanisms of ischemic brain damage[J]. Neuropharmacology, 2008, 55(3):310-318.
[17]	Heeba GH, El-Hanafy AA. Nebivolol regulates eNOS and iNOS expressions and alleviates oxidative stress in cerebral ischemia/reperfusion injury in rats[J]. Life Sci, 2012, 90(11-12):388-395.
[18]	Liu DH, Yuan FG, Hu SQ, et al. Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion[J]. Neuroscience, 2013, 229:36-48.

Full-Text