利拉鲁肽对脊髓损伤修复作用的探讨
Role of liraglutide in the repair of spinal cord injury

DOI: 10.6040/j.issn.1671-7554.0.2015.1097

Keywords: 脊髓损伤,利拉鲁肽,细胞凋亡,白细胞介素-1β,大鼠,白细胞介素-6,炎症,
Spinal cord injury,Liraglutide,Cell apoptosis,Interleukin-1β,Interleukin- 6,Inflammation,Rats

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References

[1]	Rachmany L, Tweedie D, Li Y, et al. Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice[J]. Age(Dordr), 2013, 35(5):1621-1636.
[2]	Ma T, Du X, Pick JE. Glucagon-like peptide-1 cleavage product GLP-1(9-36)amide rescues synaptic plasticity and memory deficits in Alzheimers disease model mice[J]. J Neurosci, 2012, 32(40):13701-13708.
[3]	Rowland JW, Hawryluk GWJ, Brian K, et al. Current status of acute spinal cord injury pathophysiology and emerging therapies:promise on the horizon[J]. Neurosur Focus, 2008, 25(5):2.
[4]	王旭阳, 江敦清, 陈世文. 封闭内源性NT-3在脊髓损伤后期神经元有髓神经纤维出芽中的作用[J]. 山东大学学报(医学版), 2014, 52(12):5-9. WANG Xuyang, JIANG Dunqing, CHEN Shiwen. Function of endogenous NT-3 in the regeneration sprouting of large neuron at late-stage spinal cord injury[J]. Journal of Shandong University(Health Science), 2014, 52(12):5-9.
[5]	Wang Q, Brubaker PL. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice[J]. Diabetologia, 2002, 45(9):1263-1273.
[6]	Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system[J]. J Comp Neurol, 1999, 403(2):261-280.
[7]	Holscher C. Central effects of GLP-1:new opportunities for treatments of neurodegenerative diseases[J]. J Endocrinol, 2014, 221(1):31-41.
[8]	Fleming J, Norenberg M, Ramsay D, et al. The cellular inflammatory response in human spinal cords after injury[J]. Brain, 2006, 129(Pt 12):3249-3269.
[9]	McGovern SF, Hunter K, Holscher C. Effects of the glucagon-like polypeptide-1 analogue(Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain[J]. Brain Res, 2012, 1473(6):204-213.
[10]	Poon P, Gupta DM, Tator C. Clip compression model is useful for thoracic spinal cord injuries:histologic and functional correlates[J]. Spine, 2007, 32(25):2853-2859.
[11]	Cristina H, Marta GR, Lidia C, et al. Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes[J]. Diabetes, 2013, 62(10):2569-2578.
[12]	Sato K, Kameda M, Yasuhara T, et al. Neuroprotective effects of liraglutide for stroke model of rats[J]. Int J Mol Sci, 2013, 14(11):21513-21524.
[13]	Zhang X, Li W, Li P, et al. Intraportal infusion of ghrelin could inhibit glucose-stimulated GLP-1 secretion by enteric neural net in Wistar rat[J]. Biomed Res Int, 2014, 2014(2):923564.
[14]	Krasner NM, Ido Y, Ruderman NB. Glucagon-like peptide-1(GLP-1)analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism[J]. PLoS One, 2014, 9(5):97554. doi:10.1371/journal.pone.0097554.eCollection 2014.
[15]	Jolivalt CG, Fineman M, Deacon CF. GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice[J]. Diabetes Obes Metab, 2011, 13(11):990-1000.

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