NR2B通过mBDNF参与肠易激综合征内脏高敏感的发生
NR2B contributes to visceral hypersensitivity in irritable bowel syndrome via mBDNF

DOI: 10.6040/j.issn.1671-7554.0.2016.1674

Keywords: NR2B,内脏高敏感,肠易激综合征,成熟脑源性神经营养因子,
Irritable bowel syndrome,NR2B,Mature brain-derived neurotrophic factor,Visceral hypersensitivity

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[1]	Paoletti P, Bellone C, Zhou Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease[J]. Nat Rev Neurosci, 2013, 14(6): 383-400.
[2]	Qi Q, Chen F, Zhang W, et al. Colonic N-methyl-D-aspartate receptor contributes to visceral hypersensitivity in irritable bowel syndrome[J]. J Gastroenterol Hepatol, 2017, 32(4): 828-836.
[3]	Corsetti M, Van Oudenhove L, Tack J. The quest for biomarkers in IBS-where should it lead us?[J]. Neurogastroenterol Motil, 2014, 26(12): 1669-1676.
[4]	Seo JH, Fox JG, Peek RM, et al. N-methyl D-aspartate channels link ammonia and epithelial cell death mechanisms in Helicobacter pylori Infection[J]. Gastroenterology, 2011, 141(6): 2064-2075.
[5]	Ferguson HJ, Wragg JW, Ward S, et al. Glutamate dependent NMDA receptor 2D is a novel angiogenic tumour endothelial marker in colorectal cancer[J]. Oncotarget, 2016, 7(15): 20440-20454.
[6]	Yu YB, Zuo X, Zhao QJ, et al. Brain-derived neurotrophic factor contributes to abdominal pain in irritable bowel syndrome[J]. Gut, 2012, 61(5): 685-694.
[7]	Fan J, Wu X, Cao Z, et al. Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats[J]. Gastroenterology, 2009, 136(5): 1732-1740 e3.
[8]	Marosi K, Kim SW, Moehl K, et al. 3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons[J]. J Neurochem, 2016, 139(5): 769-781.
[9]	陈飞雪, 于岩波, 王鹏, 等. 脑源性神经营养因子对小鼠回肠及结肠平滑肌收缩活动的影响及其机制[J]. 山东大学学报(医学版), 2012, 50(4): 42-46. CHEN Feixue, YU Yanbo, WANG Peng, et al. Brain derived neurotrophic factor influences contractile activity in the isolated ileum and colon of mice[J]. Journal of Shandong University(Health Sciences), 2012, 50(4): 42-46.
[10]	赵栋燕, 于岩波, 左秀丽. 脑源性神经营养因子在小鼠肠黏膜屏障中的作用[J]. 山东大学学报(医学版), 2016, 54(7): 1-5. ZHAO Dongyan, YU Yanbo, ZUO Xiuli. Brain derived neurotrophic factor modulates intestinal barrier integrity in mice[J]. Journal of Shandong University(Health Sciences), 2016, 54(7): 1-5.
[11]	Yu YB, Zhao DY, Qi QQ, et al. BDNF modulates intestinal barrier integrity through regulating the expression of tight junction proteins[J]. Neurogastroenterol Motil, 2017, 29(3). doi: 10.1111/nmo.12967. Epub 2016 Oct 17.
[12]	Willert RP, Woolf CJ, Hobson AR, et al. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor[J]. Gastroenterology, 2004, 126(3): 683-692.
[13]	Wu X, Gao J, Yan J, et al. Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats[J]. Am J Physiol Gastrointest Liver Physiol, 2008, 294(4): G918-927.
[14]	Barbara G, Cremon C, Annese V, et al. Randomised controlled trial of mesalazine in IBS[J]. Gut, 2016, 65(1): 82-90.
[15]	Traynelis SF, Wollmuth LP, McBain CJ, et al. Glutamate receptor ion channels: structure, regulation, and function[J]. Pharmacol Rev, 2010, 62(3): 405-496.
[16]	Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders[J]. Gastroenterology, 2006, 130(5): 1480-1491.
[17]	Talley NJ,Phillips SF, Melton J 3rd, et al. A patient questionnaire to identify bowel disease[J]. Ann Intern Med, 1989, 111(8): 671-674.
[18]	Wang P, Du C, Chen FX, et al. BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit[J]. Sci Rep, 2016, 6: 20320. doi: 10.1038/srep20320.
[19]	Fukuchi M, Tabuchi A, Kuwana Y, et al. Neuromodulatory effect of Galphas-or Galphaq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons[J]. J Neurosci, 2015, 35(14): 5606-5624.
[20]	Park H, Popescu A, Poo MM. Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP[J]. Neuron, 2014, 84(5): 1009-1022.
[21]	Li CY, Li SC. Treatment of irritable bowel syndrome in China: a review[J]. World J Gastroenterol, 2015, 21(8): 2315-2322.
[22]	Paoletti P. Molecular basis of NMDA receptor functional diversity[J]. Eur J Neurosci, 2011, 33(8): 1351-1365.
[23]	Reijerkerk A, Kooij G, van der Pol SM, et al. The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier[J]. J Neurochem, 2010, 113(2): 447-453.
[24]	Wang P, Chen FX, Du C, et al. Increased production of BDNF in colonic epithelial cells induced by fecal supernatants from diarrheic IBS patients[J]. Sci Rep, 2015, 5: 10121. doi: 10.1038/srep10121.
[25]	Maqsood R, Stone TW. The gut-brain axis, BDNF, NMDA and CNS disorders[J]. Neurochem Res, 2016, 41(11): 2819-2835.

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