小鼠骨硬化蛋白的转录后调控机制
Post-transcriptional regulation mechanism of sclerostin in mice

DOI: 10.6040/j.issn.1671-7554.0.2016.1068

Keywords: Wnt信号,骨硬化蛋白,成骨分化,转录后调控,3'非编码区,
Sclerostin,Osteogenic differentiation,Wnt signaling,Post-transcriptional regulation,3'Untranslated regions(UTR)

Full-Text   Cite this paper   Add to My Lib

Abstract:

References

[1]	Ivey KN, Srivastava D. microRNAs as developmental regulators[J]. Cold Spring Harb Perspect Biol, 2015, 7(7): a8144.
[2]	Deng ZL, Sharff KA, Tang N, et al. Regulation of osteogenic differentiation during skeletal development[J]. Front Biosci, 2008, 13: 2001-2021.
[3]	Li X, Ominsky MS, Niu QT, et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength[J]. J Bone Miner Res, 2008, 23(6): 860-869.
[4]	Yavropoulou MP, Xygonakis C, Lolou M, et al. The sclerostin story: from human genetics to the development of novel anabolic treatment for osteoporosis[J]. Hormones(Athens), 2014, 13(4): 323-337.
[5]	杨静, 李珊珊, 张瑾. 小鼠成骨细胞中分泌型卷曲相关蛋白1转录后调控机制的研究[J]. 中华口腔医学杂志, 2016, 51(4): 242-247. YANG Jing, LI Shanshan, ZHANG Jin. Study of post-transcriptional regulation of secreted frizzled-related protein1in MC3T3-E1 cells[J]. Chin J Stomatol, 2016, 51(4): 242-247.
[6]	Hagino H. Newly developed drugs to improve bone strength[J]. Clin Calcium, 2016, 26(1): 99-105.
[7]	Irwandi RA, Vacharaksa A. The role of microRNA in periodontal tissue: a review of the literature[J]. Arch Oral Biol, 2016, 72: 66-74.
[8]	Lewiecki EM. Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases[J]. Ther Adv Musculoskelet Dis, 2014, 6(2): 48-57.
[9]	Sharifi M, Ereifej L, Lewiecki EM. Sclerostin and skeletal health[J]. Rev Endocr Metab Disord, 2015, 16(2): 149-156.
[10]	Dole NS, Delany AM. MicroRNA variants as genetic determinants of bone mass[J]. Bone, 2016, 84: 57-68.
[11]	Hassan MQ, Maeda Y, Taipaleenmaki H, et al. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells[J]. J Biol Chem, 2012, 287(50): 42084-42092.
[12]	M.R. 格林,J. 萨姆布鲁克. 分子克隆实验指南(4)[M]. 北京: 科学出版社, 2012: 523-527.
[13]	Croset M, Santini D, Iuliani M, et al. MicroRNAs and bone metastasis: a new challenge[J]. Molecules, 2014, 19(7): 10115-10128.
[14]	Zhang J, Tu Q, Bonewald LF, et al. Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1[J]. J Bone Miner Res, 2011, 26(8): 1953-1963.
[15]	Huang C, Geng J, Jiang S. MicroRNAs in regulation of osteogenic differentiation of mesenchymal stem cells[J]. Cell Tissue Res, 2016. [Epub ahead of print]
[16]	Li J, He X, Wei W, et al. MicroRNA-194 promotes osteoblast differentiation via downregulating STAT1[J]. Biochem Biophys Res Commun, 2015, 460(2): 482-488.

Full-Text