角膜基质创伤愈合的研究进展
Research progress of corneal stromal wound healing

摘要： 角膜基质创伤愈合是一个涉及细胞调亡、迁移、增殖、分化和细胞外基质重建的复杂过程。转化生长因子β(TGF-β)系统在调控角膜基质细胞转化和基质纤维化方面具有关键作用,其失调是造成愈合后形成基质瘢痕、出现雾状混浊和视力受损的主要原因。近年来,在角膜基质创伤愈合的研究方面取得了重要进展,并开发出了一些消除基质瘢痕的新的治疗方法。本文拟围绕角膜基质的创伤愈合过程,细胞表型转化及其调控因子,以及愈合过度的控制策略进行综述。
Abstract: Corneal stroma wound healing is a complex process involving cell apoptosis, migration, proliferation, differentiation, and extracellular matrix remodeling. Transforming growth factor β(TGF-β)system plays central roles in regulating the transformation of stromal cells and the fibrosis of stroma, and its dysregulation might be the main cause of stromal haze, scar formation and vision damage. Recently, great progress has been made in the study of corneal stromal wound healing, and various new therapies to attenuate stromal scar have also been developed. The process of corneal stromal wound healing, cellular phenotype transformation and its regulating factors, and strategies of excessive healing control are reviewed