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- 2016
甲苯咪唑和芬苯达唑对灵长类动物毛首线虫的驱虫效果观察
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Abstract:
中文摘要：使用复方甲苯咪唑片剂按10 mg·kg -1×5 d、20 mg·kg -1×3 d、40 mg·kg -1×5 d和芬苯达唑粉剂按10 mg·kg -1×3 d对感染毛首线虫 Trichuris spp.的灵长类动物拌料喂服,测定用药前后每克粪样中虫卵数,计算虫卵减少率和虫卵转阴率以评估药物驱虫效果。结果表明,川金丝猴 Rhinopithecus roxellana按10 mg·kg -1×5 d、黑叶猴 Presbytis francoisi等7种动物按20mg·kg -1×3 d、短尾猴 Macaca arctoides和猕猴 M. mulatta按40 mg·kg -1×5 d用复方甲苯咪唑片剂投药后,虫卵减少率和虫卵转阴率均能达到100%,芬苯达唑的驱虫效果较差。甲苯咪唑对灵长类动物毛首线虫的驱虫效果较好,投药方便、安全。筛选出安全、高效和使用方便的抗毛首线虫药物及驱虫程序,为灵长类动物毛首线虫病的防控提供技术支持。
英文摘要：In order to screen efficient anthelmintic drug and procedure for trichuriasis in primates, the compound mebendazole tablets and fenbendazole in four different schemes (group Ⅰ: mebendazole 10 mg·kg -1×5 d, group Ⅱ: mebendazole 20 mg·kg -1×3 d, group Ⅲ: mebendazole 40 mg·kg -1×5 d and group Ⅳ: fenbendazole 10 mg·kg -1×3 d) were used to treat Trichuris spp. infection in primates. The anthelmintic efficacy was evaluated by calculating the egg reduction rate and egg negative rate. The results showed that the egg reduction rate and egg negative rate were 100% when mebendazole used as 10 mg·kg -1×5 d for Rhinopithecus roxellana, 20 mg·kg -1×3 d for Presbytis francoisi and 6 other primates and mebendazole 40 mg·kg -1×5 d for Macaca arctoides and M. mulatta. Poor anthelmintic efficacy was observed in fenbendazole treated group. This preliminary study also suggested that mebendazole was a safe and anthelmintic drug for Trichuris infection in primates. 2016,(35): 249-251,255 收稿日期：2015-10-20 DOI：10.11984/j.issn.1000-7083.20150326 分类号：S855.9 基金项目：成都大熊猫繁育研究基金项目(No.CPF2012-04) 作者简介： *通讯作者：杨光友, E-mail:guangyou1963@aliyun.com 参考文献： 顾永熙, 曹杰. 2002. 金丝猴毛尾线虫驱虫药物筛选及驱虫程序实验[J]. 中国兽医杂志, 38(11): 12-13. 韩飞, 张曼, 张周, 等. 2014. 甲苯咪唑在水产养殖中的研究进展[J]. 中国畜牧兽医文摘, 30(7): 197-198. 和占龙, 杨建发, 杨亮宇, 等. 2006. 自繁猕猴肠道寄生虫的调查报告[J]. 云南畜牧兽医, (1): 42-43. 菅复春, 张庆涛, 李少英, 等. 2008. 郑州市动物园草食动物和灵长类动物寄生虫感染情况及驱虫试验[J]. 中国农学通报, 24(5): 29-34. 蒋则孝. 1981. 甲苯咪唑[J]. 国际医学寄生虫病杂志, 8(2): 89-91. 王成东, 杨光友, 王强, 等. 2000. 佳灵三特-CA对灵长类动物内寄生虫的驱除试验[J]. 四川动物, 19(4): 252-253. 解天珍, 包燕芬. 1998. 云南滇金丝猴毛首线虫一形态相似种的发现[J]. 中国兽医寄生虫病, 6(3): 54-55. 杨光友, 张志和. 2013. 野生动物寄生虫病学[M]. 北京: 科学出版社. 周忠勇, 朱雪勇. 1997. 芬苯达唑驱除野生动物寄生蠕虫试验[J]. 中国兽医寄生虫病, 5(2): 33-34. Coles G, Bauer C, Borgsteede F, et al. 1992. World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance[J]. Veterinary Parasitology, 44(1): 35-44. Li B, Zhao B, Yang GY, et al. 2012. Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur (Lemur catta), China[J]. Parasitology Research, 111(2): 935-937. Li M, Zhao B, Li B, et al.
