基于事件相关电位P300的动物认知研究进展
Research Development of Animal Cognition Based on P300

中文摘要：P300是事件相关电位中被广泛用于研究正常人、患者和动物认知加工及其脑机制的重要电生理指标。本文就其起源、影响因素和动物类P300的研究进展进行了综述，详细论述了各动物在视觉、听觉和触觉等不同模态下的类P300的主要结论，及P300在人类和动物之间的异同，并分析了导致差异的原因。最后对研究的不足之处提出了可能的解决方案，并对基于P300的动物认知研究方向进行了展望。
英文摘要：P300 is an important and widely used electrophysiological index to study cognitive processing and the underlying neural mechanisms in normal people, patients and non-human animals. In this paper, previous studies were reviewed concerning the origin of P300, influencing factors on P300, like-P300 acquired from non-human animals especially in visual, auditory and tactile modalities. Moreover, the similarity and specificity of P300 between humans and non-human animals was compared and the possible causes resulting in these differences were discussed. Finally, some protocols for studies on animal cognition based on P300 and the possible prospects in the future was proposed. 2018,37(3): 351-359 收稿日期：2017-12-11 DOI：10.11984/j.issn.1000-7083.20170390 分类号：Q955 基金项目：国家自然科学基金项目（31672305，31372217）；四川省教育厅项目（18ZB0003） 作者简介：张小琴,女,硕士,讲师,研究方向:动物声音通讯及其神经机理,E-mail:qingerzx1982@163.com *通讯作者：方光战,E-mail:fanggz@cib.ac.cn 参考文献： 魏景汉, 罗跃嘉. 2010. 事件相关电位原理与技术[M]. 北京:科学出版社:52-55. Allen JJB. 2002. The role of psychophysicology in clinical assessment:ERPs in the evaluation of memory[J]. Psychophysiology, 39(3):261-280. Arnone B, Pompili A, Tavares MC, et al. 2011. Sex-related memory recall and talkativeness for emotional stimuli[J]. Frontiers in Behavioral Neuroscience, 5:52. Arthur DL, Starr A. 1984. Task-relevant late positive component of the auditory event-related potential in monkeys resembles P300 in humans[J]. Science, 223(4632):186-188. Barceló F, Rubia FJ. 1998. Non-frontal P3b-like activity evoked by the Wisconsin Card Sorting Test[J]. Neuroreport, 9(4):747-751. Calcus A, Deltenre P, Hoonhorst I, et al. 2014. MMN and P300 are both modulated by the featured/featureless nature of deviant stimuli[J]. Clinical Neurophysiology, 126(9):1727-1734. Dien J, Spencer KM, Donchin E. 2004. Parsing the late positive complex:mental chronometry and the ERP components that inhabit the neighborhood of the P300[J]. Psychophysiology, 41(5):665-678. Duncan CC, Barry RJ, Connolly JF, et al. 2009. Event-related potentials in clinical research:guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400[J]. Clinical Neurophysiology, 120(11):1883-1908. Ehlers CL, Desikan A, Wills DN. 2014. Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats[J]. Alcoholism Clinical and Experimental Research, 38(3):749-759.