动物线粒体基因组GC含量分析
Analysis of GC Contents in Animal Mitogenome

中文摘要：碱基组成是指基因组中腺嘌呤、鸟嘌呤、胞嘧啶和胸腺嘧啶的相对含量,一般用鸟嘌呤和胞嘧啶的含量(GC含量)表示。前人的研究表明,不同类群的核基因组GC含量存在差异, 然而,对于动物线粒体基因组碱基组成的研究却很少。为此,本文统计和分析了分属于20个门的609个动物线粒体基因组的碱基组成。结果表明,各门动物间线粒体基因组GC含量没有显著差异,不能反映各动物门间的进化关系。脊椎动物鱼纲、两栖纲、爬行纲、鸟纲和哺乳纲及其代表性目的线粒体基因组GC含量虽有一定差异,但并未发现明显的变化规律。
英文摘要：Base composition refers to the relative content of adenine, guanine, cytosine, and thymine within a genome, which is commonly represented by GC contents. Many previous studies demonstrated that the base compositions of nuclear genome as well as its features were variable in different phyla. However, few studies were concerned on the GC contents in animal mitochondrial genome. Hence, base compositions of 609 mitochondrial genomes belonged to 20 phyla were analyzed in this paper. The results indicated that the GC contents of mitochondrial genomes in animal phyla had no significant difference and could not reflect the evolutionary relationships among them. Certain differences on GC contents were observed in the vertebrates (Pisces, Amphibia, Reptile, Aves and Mammalia), but no significant rules were found. 2015,(): 107-110 收稿日期：2014-6-20 DOI：10.3969/j.issn.1000-7083.2015.01.019 分类号：Q953;Q857.3 基金项目：国家自然科学基金项目(30960051,31260088);江西省自然科学基金项目(20132BAB204022);江西省教育厅科技项目(GJJ11529), 赣鄱英才555人才工程; 江西省主要学科学术和技术带头人培养计划(20133BCB22010) *通讯作者：杨承忠,E-mail:drczyang@126.com 参考文献： 高英凯, 苗永旺, 苏小茜, 等. 2009. 74种鸟类线粒体基因组碱基组成及特征分析[J]. 云南农业大学学报, 24(1): 51-58. 刘运强, 廖顺尧, 鲁成, 等. 2001. 动物线粒体编码序列相邻碱基组成对核苷酸替换的影响[J]. 西南农业大学学报, 23(3): 270-272. 马德如. 1998. 脊椎动物基因组进化原因的争论[J]. 生命的化学, 18(1): 7-9. 孙啸, 陆祖宏, 谢建明. 2004. 生物信息学概论[M]. 北京: 清华大学出版社. 王进, 严明. 2008. 比较基因组学手册-原理与方法[M]. 北京: 化学工业出版社. 武伟, 刘洪斌, 张泽, 等. 2007. 节肢动物线粒体基因组碱基组成特征分析[J]. 生物信息学, (3): 102-105. 钟军, 赵贵军, 张振书, 等. 2002. 基因组内碱基分布整体均衡与局部不均衡的研究进展[J]. 遗传, 2493: 351-355. Argos P, Rossmann MG, Grau UM, et al. 1979. Thermal stability and protein structure[J]. Biochemistry, 18(25): 5698-5703. Avise JC, Saunders NC. 1984. Hybridization and introgression among species of sunfish Lepomis analysis by mitochondrial DNA and allozyme markers[J]. Genetics, 108: 237-255. Bernardi G, Olofsson B, Filipski J, et al. 1985. The mosaic genome of warm-blooded vertebrates[J]. Science, 228: 953-958. Bernardi G. 2000. The compositional evolution of vertebrate genomes[J]. Gene, 259: 31-43. Burridge CP. 1999. Molecular phylogeny of Nemadactylus and Acantholatris (Perciformes : Cirrhitoides: Cheilodactylidae), with implications for taxonomy and biogeography[J]. Molecular Phylogenetics and Evolution, 13: 93-109. Cheng JW, Chou SH, Reid BR. 1993. Base pairing genometry in GA mismatches depengds entirely on the