沉默交配型信息调节因子2同源蛋白1与骨和软骨代谢的关系
Silent mating type information regulation 2 homolog 1 in bone and cartilage homeostasis

摘要： 沉默交配型信息调节因子2同源蛋白（SIRT）1 是一种依赖于烟酰胺腺嘌呤二核苷酸的第3类去乙酰化酶，在骨与软骨的代谢中发挥着重要的作用。SIRT1通过促进成骨细胞生成、骨量增长、抑制破骨细胞生成，调节骨的发育和重建。此外，SIRT1还可促进骨髓间质干细胞的成骨向分化。在软骨代谢过程中，SIRT1对于软骨的改建必不可少。SIRT1在骨与软骨过程中的作用与无翅型小鼠乳房肿瘤病毒整合位点家族信号转导通路、核因子-κB信号转导通路、叉头转录因子O和甲状旁腺素密切相关。本文就沉默信息调节因子SIRT1在骨与软骨代谢中的作用、SIRT1调节骨代谢的信号转导通路等研究进展作一综述。
Abstract: Silent mating type information regulation 2 homolog(SIRT)1 is a nicotinamide adenine dinucleotide-positive dependent class 3 histone deacetylase that regulates bone and cartilage metabolism. SIRT1 influences bone development and reconstruction by potentiating osteoblast formation and bone growth and by inhibiting osteoclastogenesis. SIRT1 also activates mesenchymal stem cells to differentiate into osteoblasts. In cartilage homeostasis, SIRT1 is necessary to maintain normal cartilage remodeling. These functions of SIRT1 are related to wingless-type mouse mammary tumor virus integration site family signal transduction pathway, nuclear factor-κB signaling pathway, forkhead box O transcription factors, and parathyroid hormone. This review summarizes the function and mechanism of SIRT1 in the regulation of bone and cartilage metabolism. This review also describes the potential clinical applications of SIRT1.
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