齿垢密螺旋体糜蛋白酶样蛋白酶复合物及其致病作用
Treponema denticola chymotrypsin-like protease complex and its pathogenic features

摘要： 齿垢密螺旋体作为龈下菌斑红色复合体中的一员,与牙周炎症密切相关。其表面的糜蛋白酶样蛋白酶复合物（CTLP）是齿垢密螺旋体的一个重要的毒力因子。CTLP参与介导了齿垢密螺旋体的多种致病机制,包括对组织细胞和组织蛋白的黏附及侵入,与其他牙周致病菌协同形成致密生物膜,产生细胞毒作用,破坏上皮屏障、侵入深层牙周组织,降解组织蛋白,调节宿主源性蛋白酶的激活,引发宿主的免疫调控紊乱,具有多方面的致病作用。深入研究CTLP,有助于诠释口腔螺旋体的致病机制,丰富牙周病的病因及发病机制。
Abstract: Treponema denticola is closely associated with periodontal disease as a member of subgingival “red complex”.The surface protease chymotrypsin-like protease complex(CTLP) is an important virulent factor of T. denticola. CTLP plays significant roles in mediating pathogenesis of T. denticola, including adhesion and invasion to host cells and proteins, synergetic formation of biofilm with other periodontal pathogens, cytopathic effect, impairment and penetration of epithelial barrier, degradation of cell and tissue protein, modulation of host-derived proteinases and disruption of host immune regulation, and displaying multiple pathogenic features. Further study of CTLP will help to explain the pathogenesis of oral leptospira and to enrich the etiology and pathogenesis of periodontal diseases.
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