维吾尔族口腔鳞状细胞癌患者中血清鳞状细胞癌抗原的表达研究
Clinical significance of serum squamous cell carcinoma antigens in Uyghur patients with oral squamous cell carcinoma

摘要： 目的 探讨维吾尔族口腔鳞状细胞癌（OSCC）患者血清中鳞状细胞癌抗原（SCC-Ag）的表达。方法 采用化学发光法检测90例维吾尔族OSCC患者（OSCC组）和90例维吾尔族其他口腔恶性肿瘤患者（口腔非OSCC恶性肿瘤组）、101例维吾尔族口腔良性肿瘤患者（良性肿瘤组）和120例维吾尔族正常对照者（正常组）的血清SCC-Ag水平，并对其中60例OSCC和60例口腔非OSCC恶性肿瘤患者治疗前后SCC-Ag水平进行检测，分析SCC-Ag在OSCC诊断、治疗疗效中的意义。结果 OSCC组的SCC-Ag水平明显高于口腔非OSCC恶性肿瘤组（P=0.002），良性肿瘤组（P=0.001）和正常组（P=0.001）。OSCC患者血清SCC-Ag阳性率为43.3%（39/90），明显高于其他3组（P=0.000 1）。OSCC患者TNM晚期的术前SCC-Ag水平的表达高于早期水平（P<0.05）。复发组和未复发组的术前、术后、放化疗后SCC-Ag水平相比较，差异均有统计学意义（P<0.05）。手术及放化疗前后鳞状细胞癌患者血清SCC-Ag水平变化差异有统计学意义（P<0.01），然而，在口腔非OSCC恶性肿瘤组治疗疗效差异无统计学意义（P>0.05）。结论 血清SCC-Ag对维吾尔族OSCC患者的早期诊断敏感性不高，但在评价治疗疗效，预测肿瘤复发方面有重要的临床意义。
Abstract: Objective This study investigates the expression of squamous cell carcinoma antigen(SCC-Ag) levels in patients with Uyghur oral squamous cell carcinoma(OSCC). Methods Serum SCC-Ag levels were measured in 90 Uyghur patients with OSCC(OSCC group), 90 Uyghur patients with other oral malignant tumors(oral malignant tumor except OSCC group), 101 Uyghur patients with oral benign tumors(benign tumor group), and 120 healthy Uyghur people(healthy group). SCC-Ag levels were measured in 60 OSCC cases and 60 cases of oral malignant tumor except OSCC before and after treatment. The significance of SCC-Ag in the diagnosis and treatment of OSCC was analyzed. Results SCC-Ag levels in OSCC group were significantly higher than in oral malignant tumor except OSCC group(P=0.002), benign tumor group(P=0.001), and healthy group(P=0.001). Serum SCC-Ag positive rate in OSCC group was 43.3% (39/90) and was significantly higher compared with the other three groups(P=0.000 1). SCC-Ag expression was higher in preoperative OSCC group in late TNM stage compared with patients in early TNM stage(P<0.05). Preoperative and postoperative patients who received radiation and chemotherapy treatment were further classified into the recurrence group and non-recurrence group, the difference in SCC-Ag levels between groups was statistically significant(P<0.05). The difference between SCC-Ag levels in groups with squamous carcinoma before and after surgical, radiation, and chemotherapy treatment was statistically significant(P<0.01). However, the curative effect of SCC-Ag levels in oral malignant tumor except OSCC group was not statistically significant(P>0.05). Conclusion Serum SCC-Ag levels were not highly sensitive in Uyghur patients with early-stage OSCC. However, SCC-Ag has clinical significance in the evaluation of curative effect as a predictor of tumor recurrence