CD20在口腔潜在恶性病变中的表达及其临床意义
Clinical significance of CD20 expression in oral potentially malignant disorders

摘要： 目的 从组织学层面上探究B淋巴细胞特有的表面标记物CD20在口腔潜在恶性病变（OPMD）组织中的表达情况,评估CD20在口腔黏膜组织癌变过程中的表达规律及其临床意义。方法 采用回顾性分析研究的方法,分别分析17例上皮增生、21例口腔扁平苔藓（OLP）、15例上皮轻度异常增生（D1）、9例上皮中度异常增生（D2）共计4组样本的临床资料,采用免疫组织化学染色（IHC）技术检测各组病理组织中CD20的表达情况,分析CD20的表达与病理分型以及各临床因素之间的关系。结果 在上皮增生、OLP、D1、D2四组样本中,CD20阳性染色率分别为11.76%、61.90%、20.00%、66.67%,组间差异有统计学意义（P<0.05）。CD20的阳性表达与年龄、性别、部位、吸烟饮酒史等因素均无相关性（P>0.05)。多因素分析结果显示,将上皮增生组作为参考时,OLP组和D2组的比值比升高,差异有统计学意义（P<0.05）。结论 CD20可以作为一项评估OPMD恶性转化潜能的临床指标。
Abstract: Objective This study aims to investigate the expression of C20 in oral potentially malignant disorders (OPMDs) by using the histological analysis and evaluates the clinical value of using CD20 as indices to assess the carcinogenic potential of OPMDs.Methods Clinical data from 17 cases with oral hyperplasia mucosa, 21 cases with oral lichen planus (OLP), 15 cases with mild oral dysplasia mucosa (D1), and 9 cases with mild moderate dysplasia mucosa (D2) were analyzed by using retrospective analysis. Immunohistochemical analysis was applied to investigate the expression of CD20 in paraffin sections of oral hyperplasia mucosa, OLP, D1, and D2 tissues. Subsequently, the relationships between such expression and clinical factors were investigated.Results Results The positive rates of CD20 expression in the oral hyperplasia mucosa, OLP, D1, and D2 mucosa were 11.76%, 61.90%, 20.00%, and 66.67% (P<0.05), respectively. CD20 expression was found uncorrelated with age, gender, region, alcohol use, and smoking status (P>0.05). The multiple-factor analysis showed that the odds ratios of OLP and D2 significantly increased (P<0.05) when oral hyperplasia mucosa was used as the reference group. Conclusion CD20 may be used individually as clinical index to evaluate the carcinogenic potential of OPMDs.
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