唾液腺乳腺样分泌癌的研究进展
Research progress on mammary analogue secretory carcinoma of salivary gland

摘要： 唾液腺乳腺样分泌癌（MASC）是一种近年来才被描述的唾液腺肿瘤新类型，因其存在与乳腺分泌性癌类似的特异性的E-二十六变异基因6-神经营养酪氨酸受体激酶3融合基因而得名。MASC在病理形态上非完全特异，与诸多唾液腺肿瘤有重叠，所以在病理诊断中经常将其诊断为腺泡细胞癌或黏液表皮样癌等。本文就MASC的临床表现、病理特点、分子生物学特征、鉴别诊断、预后和治疗等研究进展作一综述。
Abstract: Mammary analogue secretory carcinoma(MASC) is a salivary gland tumor that harbors the specific E-twenty six variant gene 6-nerve nutrition tyrosine receptor kinase 3 translocation which resembles secretory carcinoma of the breast. MASC exhibits morphological features similar to other salivary gland tumors and is thus often pathologically diagnosed as acinic cell carcinoma and mucoepidermoid carcinoma. This paper reviews the clinical manifestations, pathological features, molecular characteristics, differential diagnosis, prognosis, and treatment of MASC