精氨酸-甘氨酸-天冬氨酸修饰钛材料表面的研究进展
Research progress on arginine-glycine-aspartic acid peptide and its derivatives in the surface biological modification of pure titanium and its alloys

摘要： 钛及其合金因良好的生物学性能被广泛应用于口腔医学领域，但钛金属是惰性材料，植入后不能直接和骨形成较好的结合，因此对钛及其合金表面进行生物改性一直是生物材料领域的研究热点。精氨酸-甘氨酸-天冬氨酸（RGD）作为钛材料表面修饰的候选蛋白质，广泛存在于纤连蛋白、玻连蛋白和骨涎腺蛋白等多种细胞外基质蛋白中，可调节细胞与血清及细胞外基质的附着，因此，本文就目前国内外对RGD修饰钛及其合金表面的主要研究进展作一综述。
Abstract: Titanium and its alloys have excellent biological properties for wide used as dental and orthopedic implant materials. However, titanium is an inert material and cannot be directly osseointegrated with bone after its implantation. Therefore, surface biological modification of pure titanium and its alloy has been a research focus in the field of biological materials. Arginine–glycine–aspartic acid(RGD) peptides, namely, the RGD tripeptide sequence, are a candidate protein in the surface modification of titanium, which are widely present in fibronectin, vitronectin, bone salivary gland proteins, and other extracellular matrix proteins, and can regulate adhesion behavior of cell-serum and cell-extracellular matrix. Therefore, this article seeks to review the study and progression on surface biological modification of pure titanium and its alloys treated by RGD peptide and its derivatives.
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