Dickkopf 1与骨破坏性疾病的关系
Relationship between Dickkopf 1 and bone destruction

摘要： Dickkopf（DKK）1是一种分泌型糖蛋白，为无翅型小鼠乳房肿瘤病毒整合位点家族（WNT）信号转导通路的重要抑制因子之一，可通过与低密度脂蛋白受体相关蛋白5/6等WNT受体复合体的结合来抑制WNT信号转导通路的信号转导。DKK1既在骨质疏松症、类风湿关节炎、多发性骨髓瘤和牙周炎等疾病中都存在着异常表达，亦在骨代谢中发挥重要的作用。本文就近年来DKK1与骨破坏性疾病的关系等研究进展作一综述，以抑制骨破坏和修复骨损失为最终研究目的，为治疗牙周炎和获得牙槽骨再生寻找新的途径。
Abstract: Dickkopf(DKK) 1 is an important inhibitory factor of the wingless-type mice mammary tumour virus integration site family(WNT) signal transduction pathway. DKK1 binds to the low-density lipoprotein receptor-related protein-5/6 of the WNT receptor to inhibit the signaling pathway. DKK1 is abnormally expressed in osteoporosis,rheumatoid arthritis, multiple myeloma, and periodontitis. DKK1 also plays a significant role in bone metabolism. This review summarizes the research progress on DKK1 and bone destructive diseases to help establish strategies that can inhibit bone destruction and repair bone defects. This review also provides a basis for the development of novel techniques to treat periodontitis and to promote periodontal bone regeneration