粪肠球菌与巨噬细胞相互作用机制的研究进展
Progress in the interactive mechanism between Enterococcus faecalis and macrophages

摘要： 粪肠球菌（Enterococcus faecalis）是难治性根尖周炎的主要致病菌,脂磷壁酸是其主要免疫原和重要毒力因子。作为天然免疫反应的重要成员,巨噬细胞在吞噬杀灭微生物、呈递抗原和分泌多种细胞因子调控机体的炎症反应等方面起了重要作用。粪肠球菌在与宿主巨噬细胞的长期相互作用过程中,也逐渐形成了多种逃避杀灭的有效策略,得以在宿主体内存活并增殖。本文就巨噬细胞抵抗粪肠球菌感染及粪肠球菌逃避巨噬细胞杀灭两方面的研究进展进行综述。
Abstract: Enterococcus faecalis is the main pathogen of refractory apical periodontitis. Lipoteichoic acid is the main immunogen and an important virulence factor of such infection. Macrophages, which are an important member of the natural immune response, are crucial in phagocytosis of microbes, presentation of antigens and secretion of various cytokines to regulate the inflammatory response of the body. In the long-term interaction with the host macrophages, E. faecalis gradually forms a variety of effective strategies for survival and proliferation. This review focuses on the resistance of macrophages to E. faecalis and the strategies of E. faecalis to avoid killing macrophages.
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