第一秒用力呼气量与肺癌患者术后肺部感染的相关性

目的 研究肺功能指标第一秒用力呼气量（forced expiratory volume in one-second, FEV1）与肺癌患者行手术治疗后发生肺部感染的关系。方法 以行肺癌手术治疗的124例患者为研究对象，根据术后是否发生肺部感染分为肺部感染组（24例）和无感染组（100例），分析术后肺部感染的相关因素；并以FEV1为变量，构建术后肺部感染模型，计算其灵敏度。结果 两组在既往合并糖尿病病史、吸烟指数、FEV1方面，术后肺部感染组与无感染组存在明显差异（P<0.05）；而在手术方式、手术时间以及既往呼吸系统病史方面差异无统计学意义（P>0.05）。以FEV1为变量构建预防术后肺部感染的预测效能，结果显示AUC为0.652（95%CI： 0.540～0.752），灵敏度83%，特异度52%。结论 FEV1与肺癌患者外科手术后并发肺部感染关系密切，FEV1为肺癌术后肺部感染的有效预测因子。
Objective To investigate the relationship between lung function index forced expiratory volume in the first second (FEV1%) and lung infection after lung cancer operation. Methods One hundred and twenty four patients with lung cancer receiving surgical treatment in our department from January 2012 to January 2018 were enrolled in the study, among whom postoperative pulmonary infection developed in 24 cases (19.4%). The factors related to postoperative pulmonary infection was analyzed, and the predictive model for postoperative pulmonary infection was established. Results There were significant differences in the history of diabetes, smoking index and FEV1% between the postoperative pulmonary infection group and non-infection group (P<0.05), while there was no significant difference in the mode of operation, the operation time and the history of the previous respiratory disease between two groups (P>0.05). Using FEV1% as a predictive indicator of postoperative pulmonary infection, the AUC was 0.652 (95%CI: 0.540-0.752), sensitivity and specificity were 83% and 52%, respectively. Conclusion FEV1 is related to lung infection after surgery in patients with lung cancer, and it may be used as an indicator to predict the postoperative pulmonary infection