ClC-2在癫发病机制中的研究进展

ClC-2是一种电压门控氯通道,在稳定细胞膜电位、调节细胞兴奋性方面有重要意义。但其在癫发病机制中所起的作用仍不清楚。本研究就ClC-2的各项研究进展,包括ClC-2的结构与功能、ClC-2在癫动物模型中的改变以及在癫患者中ClC-2基因表达异常与癫发病的相关性进行综述。
ClC-2 is a member of the supergene family of voltage-gated chloride channels. It is proved to be inwardly rectifying, and plays an important role in setting the intracellular chloride concentration in neurons expressing inhibitory GABAA receptors. The role of ClC-2 in epilepsy is still not clear. Here, we review the structures and functions of ClC-2 and changes of ClC-2 in experimental epileptic models. This article try to analyze the correlation between ClC-2 and epilepsy