非他汀类抗动脉粥样硬化药物治疗研究进展

心血管疾病是现代社会严重威胁人类健康,引起死亡的主要疾病。其中,冠状动脉粥样硬化性心脏病(coronary atherosclerosis heart disease, CAD)占90%以上。心血管疾病已经成为我国医疗保健系统的沉重负担。目前,临床上治疗多应用3羟甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂(他汀类药物)来抗动脉粥样硬化。本综述通过对目前动脉粥样硬化形成机制研究的介绍,阐述抗动脉粥样硬化研究的基本方向。分析目前他汀类药物抗动脉粥样硬化的机制及研究进展。
Cardiovascular disease has become a major health threat in China, and coronary atherosclerotic heart disease(CAD) accounts for more than 90% of all heart diseases. HMG-CoA reductase inhibitors(statins) can reduce LDL-C level and are the main medication for CAD patients. This article reviews the recent progress on the mechanism of atherosclerosis, the effect of statins and the new research direction and perspectives of non-statin anti-atherosclerosis drugs in the future