住院结核患者合并静脉血栓栓塞症的危险因素分析

目的 分析住院结核患者合并静脉血栓栓塞症(venous thromboembolism, VTE)的危险因素。方法 收集2013年1月至2014年6月结核患者9387例,合并VTE的患者32例作为观察组(VTE组),非VTE组患者采取随机方法选取病例作为对照组(非VTE组),比较两组间各项观察指标,进行单因素分析。对差异有统计学的指标进行多因素分析,以发现结核患者导致VTE的多种相关因素。单因素分析采用χ2检验,多因素分析采用双元logistic回归分析。结果 9387例住院结核患者中,32例合并VTE,占住院结核患者的0.341％(32/9387)。经多因素分析,年龄＞65岁、长期卧床状态、血白细胞计数增加、D-二聚体升与住院患者发生VTE有关,均为危险因素。结论 住院结核患者中,高龄、长期卧床状态者更易发生VTE。
Objective To investigate the risk factors of venous thromboembolism(VTE) in patients with tuberculosis. Methods Total 9387 patients with tuberculosis were admitted between January 2013 and June 2014, among whom VTE developed in 32 patients(VTE group) and rest 9355 patients served as control group. The risk factors of VTE were determined with univariate and multivariate analyses, Chi-square test and binomial logistic regression. ResultsMultivariate analysis revealed that age ＞65 years, long-term immobilization, elevated white blood cell counts, elevated D-Dimer level were risk factors of VTE. Conclusion Tuberculosis patients with advanced age and long-term immobilization are more inclined to develop venous thromboembolism