呼吸锻炼联合噻托溴铵治疗稳定期慢性阻塞性肺疾病的疗效观察

目的观察呼吸锻炼联合噻托溴铵对稳定期慢性阻塞性肺疾病(chronic dostructive pulmonary disease, COPD)患者临床症状、肺功能的影响。方法将65例稳定期COPD患者按随机数字表随机分为对照组(32例)及治疗组(33例)。对照组给予噻托溴铵1粒/d,吸入治疗,治疗组在对照组基础上增加呼吸锻炼。每组均治疗5周,观察治疗前后相应症状、肺功能(FEV1、FVC、FEV1/FVC)、Borg呼吸困难评分、生活质量评分的变化。结果治疗前,咳嗽、喘促程度的两组组内比较,肺功能FEV1及FEV1/FVC,Borg呼吸困难评分,生活质量评分的治疗组治疗前比较有统计学差异(P<0.05)。治疗后,喘促程度、肺功能FEV1及FEV1/FVC)、Borg呼吸困难评分、生活质量评分的组间比较有统计学差异(P<0.05)。治疗后,咳嗽、咳痰程度组间比较,肺功能的FVC无统计学差异(P＞0.05)。 治疗前、后,治疗组咳嗽、喘促程度、FEV1、FEV1/FVC、Borg呼吸困难评分、生活质量评分差异均有统计学意义(P<0.05),对照组咳嗽、喘促程度差异均有统计学意义(P<0.05)。治疗后,治疗组喘促程度、FEV1、FEV1/FVC、Borg呼吸困难评分、生活质量评分改善优于对照组,差异有统计学意义(P<0.05)；咳嗽、咳痰、FVC差异无统计学意义(P>0.05)。结论 呼吸锻炼联合噻托溴铵能提高稳定期COPD患者的肺功能,明显改善咳嗽、喘促症状。
Objective To evaluate the clinical effects of respiratory training combined with tiotropium bromide for patients with chronic obstructive pulmonary disease(COPD) in remission period. MethodsSixty-five COPD patients at stable stage were randomized into two groups: 33 patients in respiratory training group received respiratory training with tiotropium bromide treatment for 5 weeks and 32 patients in control group were treated with tiotropium bromide alone. The clinical symptoms, pulmonary function, Borg dyspnea score and the quality of life score were evaluated in two groups. ResultsThe degree of cough, shortness of breath, FEV1, FEV1 / FVC, Borg dypnea score, quality of life score had significant differences before and after treatment in treatment group(P<0.05), while in control group, only the degree of cough and shortness of breath had significant differences before and after treatment(P<0.05). After treatment, shortness of breath, FEV1, FEV1 / FVC, Borg dyspnea score, quality of life score in respiratory training group were better than those in control group (P<0.05). There were no significant differences in the degree of cough, sputum and the lung function of FVC after treatment between two groups (P>0.05). ConclusionRespiratory training combined with tiotropium bromide treatment can improve clinical symptoms, pulmonary function, Borg dyspnea score and the quality of life score in COPD patients with in stable stage