复方甘草酸苷联合丹参酮治疗中度痤疮的疗效观察

目的 观察复方甘草酸苷联合丹参酮胶囊治疗中度寻常型痤疮的疗效与安全性。方法79例中度寻常型痤疮患者随机分为两组。治疗组40例,口服复方甘草酸苷片和丹参酮胶囊；对照组39例,口服丹参酮胶囊。两组患者在口服药物同时均外用护肤粉刺霜。疗程均为8周。于用药前、用药后2、4、8周末分别记录面部各种皮损的实际数目、全身以及局部不良反应。并分别在用药前、用药后8周检测血清肿瘤坏死因子α(TNF-α)、白介素8(IL-8)、白介素10(IL-10)水平。结果治疗8周后治疗组与对照组有效率分别为82.5％、60.52％(P=0.028),表明治疗组有效率明显高于对照组；复方甘草酸苷联合丹参酮治疗后痤疮复发率低、无明显不良反应。此外,治疗组患者血清IL-8水平由153.9±17.74pg/ml降为80.5±23.91pg/ml(P＜0.01)；TNF-α水平由45.3±6.49pg/ml下降到19.5±4.87pg/ml(P＜0.01)；IL-10水平由153.0±38.89pg/ml上升至261.3±15.60pg/ml(P＜0.01)。对照组患者血清IL-8水平由156.2±18.40pg/ml下降为129.7±6.24pg/ml(P＜0.01)；TNF-α水平由46.5±7.46pg/ml下降为30.9±2.63pg/ml(P＜0.01)。对照组血清IL-10水平在治疗前后无明显改变(P＞0.05)。治疗后,治疗组血清IL-8、TNF-α的水平均较对照组显著降低(P＜0.01)而治疗组IL-10的水平较对照组显著升高(P＜0.01)。结论复方甘草酸苷联合丹参酮是治疗中度寻常型痤疮安全、有效的方法,且具有调节患者血清TNF-α、IL-8、IL-10水平的作用。
Objective To assess the therapeutic efficacy and safety of tanshinone capsule combined with compound glycyrrhizin in treatment of moderate vulgaris acne. Methods Seventy nine patients with moderate vulgaris acne were randomly assigned to trial group (n=40) or control group (n=39). Patients in trial group were treated with tanshinone capsule combined with tablet compound glycyrrhizin, and those in control group received tanshinone capsule alone. The hospital-prepared skin acne cream was locally applied onto the eruptions for patients in both groups. The course of treatment in both groups lasted for 8 weeks. The number of lesions and adverse reactions were recorded before and after 2,4,8 week of treatment. The serum levels of tumor necrosis factor α (TNF-α), interleukin-8 (IL-8) and interleukin-10 (IL-10) were detected before and after treatment. Results The overall effective rate was 82.5％ in trial group and 60.52％ in control group (P=0.028) after the therapy,respectively. In trial group, recurrence rate was lower and no major adverse reactions were encountered. In trial group the serum IL-8 levels were decreased from 153.9±17.74 pg/ml to 80.5±23.91 pg/ml (P＜0.01), TNF-α levels decreased from 45.3±6.49 pg/ml to 19.5±4.87 pg/ml (P＜0.01); IL-10 levels increased from 153.0±38.89 pg/ml to 261.3±15.60 pg/ml (P＜0.01). In control group, the serum IL-8 levels were decreased from 156.2±18.40 pg/ml to 129.7±6.24pg/ml (P＜0.01); TNF-α levels decreased from 46.5±7.46 pg/ml to 30.9±2.63 pg/ml (P＜0.01); however, there was no change in IL-10 levels after treatment (P＞0.05). After treatment, the IL-8 and TNF-α levels in trial group was lower than control group (P＜0.01), and IL-10 levels was higher than control group (P＜0.01). Conclusion Tanshinone capsule combined with compound glycyrrhizin is safe and effective in treatment of moderate