大黄治疗肾脏病安全性探析
Safety of rhubarb in treating renal disease

大黄是一种最常用且有效治疗肾脏病的中草药。但是由于其苦寒之性易伤正气，所以临床使用仍需要谨慎。实验研究和临床试验表明大黄素对慢性肾脏病存在保护作用，其有效性可能来源于对TGF-β和细胞代谢的抑制。大黄通过对肾小管和系膜细胞独特、多重的影响预防肾脏病进展，但同样存在毒性。本文讨论使用大黄治疗肾脏病减毒增效的策略。
Rhubarb is one of effective Chinese herbal medicines for renal disease and the most used one as well.However, it should be used carefully due to its bitter and cold nature, which may destroy the Zhengqi in the body.Laboratory experiments and clinical trials have showed that emodin has a renoprotective effect against the developmentof chronic kidney disease. The effect may be resulted from the inhibition of TGF-β activity and cell metabolism. Rhubarbmay prevent the progression of renal disease by multiple effects on the metabolism of renal tubules and mesangial cells,and meanwhile its toxicity may exist. This paper discusses the strategies of using rhubarb to increase its efficacy in treatingrenal disease and to avoid the adverse effect as well