β-受体阻滞剂不再降低患者死亡率吗？
Do beta blockers no longer decrease mortality?

β-受体阻滞剂主要是拮抗儿茶酚胺对β-受体的激动作用，在使相应脏器减压休息的基础上利于其功能的休整和恢复。但在循环系统尚不能完成或该类药物的使用使循环系统无法完成其最基本的生理功能条件下，β-受体阻滞剂的使用或过量使用无疑会加重脏器血流灌注不足，过度干扰机体自身调节，进而形成恶性循环，在加重其他系统功能损伤的同时，也不利于心血管系统自身功能恢复。故该类药物在心血管疾病中使用时，心脏必须有一定的代偿功能，且对循环系统功能的干扰必须小于其最大代偿功能，如此才能有利于脏器功能的保护，降低患者死亡率，否
The main pharmacological mechanism of beta blockers is to antagonize the action of catecholamines onbeta receptors to make corresponding organ function recover. But when the circulatory system can not fulfil the basicphysiological function, no matter whether it is caused by the use of the drugs, the administration or excessive use of betablockers will definitely aggravate the perfusion deficiency of organs, which interferes with the body’s own adjustment andthen leads to a vicious circle of exacerbating the function damage to all other organs as well as hindering the recovery ofcardiovascular system function. Therefore, only when the heart has certain compensatory function and the interferenceof the drugs is less than the maximum compensatory function of the circulatory system, can the drugs that be given forcardiovascular diseases be conducive to the protection of the organ function and decrease the mortality, otherwise they mayincrease the mortality rate