Oral administration of hyperoxygenatedsolution for the prophylaxis of gastric ulcerationinduced by stress or Helicobacter pylori
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Oxygen was first discovered by Sweden chemist Scheele in 1773 and convinced as an essential factor forliving by French scientists in 1777. To tackle with different hypoxic emergencies, corresponding medical approaches,e.g. mask or nasal catheter oxygen inhalation, breathing machine, hyperbaric oxygen therapy etc., have been contrived insuccession. However, one mortal trouble exists in all these conventional ways, i.e. they must rely on the ventilation and gasexchange via lungs, thus not being able to promptly render oxygen to specific hypoxia tissues. Hyperoxygenated solution(HOS), a new kind of medical liquid which can be orally taken or intravenously administrated, has been widely applied asan auxiliary method of offering oxygen in China. A large number of experiments have proved its validity in the treatmentof myocardial and cerebral ischemia/reperfusion injury, nerve lesions, shock, respiratory diseases, neonatal hypoxia andso forth. These findings suggest that HOS might not only play a role of increasing oxygen pressure in local region, butalso conspicuously contribute to improving the pathologic process of hypoxia, which coincidently is the vital link instress-induced lesions in the gastrointestinal tract. Additionally, Helicobacter pylori (H. pylori), a kind of microaerophilic(anaerobic) bacterium which can hardly survive in an aerobic atmosphere, has also been identified as an independent riskfactor for the occurrence and development of ulceration. Considering the etiology of peptic ulceration and the features ofHOS, we hypothesize that drinking HOS might prevent gastric ulceration caused by stress or anaerobic H. pylori.