糖尿病心肌细胞离子通道改变研究进展

越来越多的证据表明糖尿病会导致一种特异性心肌病——糖尿病心肌病(diabetic cardiomyopathy,DCM),其独立于其他心血管疾病。DCM患者易合并多种心律失常,发病率和死亡率很高,且心电图常显示QT间期延长。离子通道的改变是导致动作电位时程延长的基础,主要涉及钙离子、钾离子和钠离子通道的改变,本文对DCM患者离子通道改变的相关研究作一综述。
There is a growing body of evidence that diabetes mellitus leads to a specific cardiomyopathy--diabetic cardiomyopathy (DCM), which is apart from vascular disease. Lethal cardiac arrhythmia is frequently found in DCM patients, which is associated with prolongation of the QT interval in electrocardiogram (ECG), causing increased mortality in the patients with diabetes mellitus. The change of ion channel is the basis for the prolonged cardiac action potential duration, mainly involving the change of calcium ions, potassium channels and sodium channels. In this paper we reviewed the recent progress in the changes of the ion channel in DCM patients