二代测序在胶质瘤研究与个体化治疗中的应用

脑胶质瘤是一类高度致死性恶性肿瘤，目前有关其在基因组学的研究及临床治疗存在诸多挑战。二代测序技术具有高通量优势，能通过对肿瘤全基因组、外显子组、转录组及表观遗传组全面分析加深对肿瘤基因组学的认识，并已成功应用于部分肿瘤的临床研究中，为肿瘤个体化靶向治疗提供合适可行的指导。当前，运用二代测序研究胶质瘤已成为热点，将全面阐明胶质瘤致病机制，并为制定个体化治疗方案提供策略，使患者获益。
Glioma is a highly lethal malignancy and multiple challenges remain for it in the genomic study and clinical treatment. Next-generation sequencing (NGS) holds many advantages, and NGS can comprehensively analyze the whole genome, exome, transcriptome and epigenome to deepen the understanding of tumor genomics; and now, it has been successfully applied in the clinical study of some tumors, especially in personalized treatment for these tumors. At present, NGS has also been a hot in glioma research to clarify the pathogenesis of glioma, so as to draw up a personalized treatment method to benefit the patients