炎性细胞因子与胃癌的关系

炎性细胞因子与胃癌的发展过程密切相关，促炎细胞因子和抗炎细胞因子及其相关的信号通路通过不同途径，对胃癌的发生、发展以及预后等阶段起到了不同作用。本文综述了幽门螺杆菌、IL-1β、TNF-α、IL-8、TGF-β、IL-10、IL-18和T淋巴细胞在胃癌组织或血液中的表达及功能，并将这些炎性细胞因子及其相关信号通路作为胃癌的治疗靶点也做了进一步总结。
Inflammatory cytokines are closely related to the development of gastric cancer. Pro-inflammatory cytokines, anti-inflammatory cytokines and their associated signaling pathways play different roles on the stages of gastric cancer, such as occurrence, development and prognosis, through different channels. This article summarizes the expression and function of Helicobacter pylori, IL-1β, TNF-α, IL-8, TGF-β, IL-10, IL-18 and T lymphocytes in gastric tissue or blood. The inflammatory cytokines and their associated signaling pathways which working as therapeutic targets for gastric cancer are also concluded