桂圆核对记忆障碍小鼠学习记忆能力的影响

以东莨菪碱和乙醇分别造成小鼠学习记忆获得障碍和记忆再现障碍，采用迷津法和避暗法观察并比较桂圆核提取物和吡拉西坦对记忆障碍小鼠学习记忆能力的影响。结果显示：记忆障碍模型制作成功（与生理盐水组比较，在两种模型两种方法中，模型组小鼠的错误次数增加，潜伏期缩短，遭电击时间延长，均P＜0.05）。桂圆核（1.2 g/kg和 2.4 g/kg）及吡拉西坦片（0.5 g/kg）均可使记忆障碍小鼠的避暗潜伏期延长，遭电击时间缩短，避暗与迷宫中的错误反应次数减少（与模型组比较，P＜0.05）。在实验观察剂量下，桂圆核提取物的作用呈现出剂量依赖性，高剂量组与吡拉西坦的效果相近（P＞0.05）。结果表明，桂圆核对小鼠的学习和记忆障碍有改善作用。其作用机制有待进一步研究。
In the aquired dysmnesia and reproduction memory disorders models caused by scopolamine and alcohol respectively，maze test and step-through test were used to observe and compare the effects of longan seed and piracetam on learning and memory ability in dysmnesia mice. The results showed that the extract of longan seed can obviously improve the learning and memory ability. As compared with model group，extract of longan seed at the dose of 1.2 g?kg-1 and 2.4 g?kg-1 could prolong the latent period（P<0.05），reduce error hits（P<0.05） and shorten reaction time（P<0.05）. There was no significant difference between the longan seed and piracetam （P＞0.05）. In summary，the longan seed can obviously improve the learning and memory ability in dysmnesia mice ，and the mechanism of improvement can be studied in further research