Advances of Human Epididymis Protein 4 in Lung Cancer

Human epididymis 4 (HE4) belongs to whey acidic 4-disulfide center protein family. It has the characteristics of inhibiting trypsin and high expression in the serum or malignant pleural effusion of patients with lung cancer. Clinical data showed that it has certain relevance to the diagnosis and prognosis of lung cancer. HE4 may be a new indicator of clinical diagnosis and prognosis evaluation.