脊髓电刺激对心肌缺血和心肌梗死作用的研究进展

心肌缺血和心肌梗死后致死性心律失常、心力衰竭和心脏性猝死严重威胁人类健康。近年来研究资料显示，脊髓电刺激可平衡自主神经活性，抑制损伤心肌结构重构，改善缺血心肌的血流量，有效降低心肌缺血和心肌梗死后心律失常、心力衰竭和心脏性猝死的发生率，但其具体机制尚未完全阐明。脊髓电刺激改善心功能的机制可能是抑制神经重构，也可能是改善结构重构和电重构。本文就脊髓电刺激在心肌缺血和心肌梗死中的作用及其机制的研究进展进行综述。
Abstract: Fatal arrhythmias, heart failure, and sudden cardiac death after myocardial ischemia/infarction are serious threats to human health. In recent years, studies have shown that spinal cord stimulation (SCS) can balance autonomic activity, inhibit myocardial structural remodeling, improve blood flow to ischemic myocardium, effectively reduce the incidence of arrhythmia, heart failure and sudden cardiac death after myocardial ischemia/infarction, but its specific mechanism has not yet been fully elucidated. The effect of SCS on cardiac function may be achieved by inhibiting neural remodeling, or by ameliorating structural remodeling and electrical remodeling. This article reviews the progress on the role and mechanism of SCS in myocardial ischemia/infarction. Key words: Electric stimulation Spinal cord Arrhythmias Myocardial ischemia Myocardial infarction Autonomic nervous system/physiopathology Review