棕色脂肪组织及其与多囊卵巢综合征关系的研究进展

棕色脂肪组织通过线粒体的脂质氧化解偶联产热参与人体的能量平衡，预测可成为预防和治疗代谢相关疾病的新靶点。多囊卵巢综合征（PCOS）患者除伴有生殖功能障碍外还普遍存在糖脂代谢异常，动物模型研究提示移植棕色脂肪组织可改善其临床表型。通过研究棕色脂肪在PCOS疾病发生发展中的作用，可以为预防和治疗该疾病提供新的思路。
Abstract: Brown adipose tissue (BAT) holds great promise for the prevention and treatment of metabolism diseases through thermoregulation. Polycystic ovary syndrome (PCOS) is a complex condition with anovulation, hyperandrogenism, and polycystic ovaries, and also manifests glucolipid metabolic disorders. Recent researches have shown that transplantation of BAT into a PCOS rat could significantly alleviate the phenotypes. This article reviews the role of BAT in pathogenesis of PCOS, which may provide information for prevention and treatment of PCOS. Key words: Adipose tissue, brown Polycystic ovary syndrome Metabolism Review