半乳糖凝集素1在母胎界面参与胚胎着床和妊娠维持的研究进展

半乳糖凝集素1（Gal-1）是半乳糖凝集素家族的一员，它广泛存在于多种组织和细胞内，参与细胞的黏附、增殖、凋亡和炎症反应等多种病理生理过程。近年来研究显示，Gal-1在母胎界面表达丰富，它不仅影响滋养细胞的增殖、分化和侵袭，也在子宫内膜容受性的建立、胎盘血管形成及母胎免疫耐受中扮演重要角色。本文就Gal-1在母胎界面的表达及其参与胚胎着床和妊娠维持的研究进展做一综述，旨在为早期妊娠丢失和妊娠相关疾病的早期诊断、预后判断及治疗提供新的思路。
Abstract: As a member of galectins family, galectin-1(Gal-1)is widely expressed in tissues and cells, and participates in a variety of physiological and pathological processes, such as cell adhesion, proliferation, apoptosis and inflammatory reaction. Recently, it has been found that Gal-1 is highly expressed at the maternal-fetal interface and plays important roles in trophoblast cell proliferation, differentiation and invasion, endometrial receptivity, placental angiogenesis and maternal-fetal immune tolerance. In this review, we outline the expression of Gal-1 at the maternal-fetal interface and the involvement of Gal-1 in embryo implantation and pregnancy maintenance, to provide novel insights for the early diagnosis, prognostic assessment and treatment of early pregnancy loss and pregnancy-related diseases. Key words: Galectin 1 Pregnancy Embryo implantation Placenta Trophoblasts/cytology Immune tolerance Review