Vav1对T细胞的调控作用及其与相关疾病的关系

Vav1作为T细胞受体下游的关键信号分子，拥有鸟苷酸交换因子功能的催化核心结构DH-PH-ZF和接头蛋白功能的SH3-SH2-SH3结构，因而在T细胞发育、活化、增殖和功能发挥等各个阶段，以及在自身免疫性疾病、移植排斥和肿瘤等发生、发展中具有不同的调控作用，可为临床治疗提供潜在靶点。本文综述了Vav1对T细胞的调控作用及其与相关疾病的关系。
Abstract: Vav1, as a key downstream signaling molecule of T cell receptor, includes a catalytic core DH-PH-ZF domain with the function as guanine nucleotide exchange factor (GEF), and a SH3-SH2-SH3 domain with the function as adaptor protein. These two structures of Vav1 play different roles in the development, activation, proliferation and function of T cells, and thereby exert the different regulatory effect on the occurrence and development of autoimmune disease, graft rejection, cancer and other clinical conditions, implicating that Vav1 might be a potential therapeutic target for these diseases. This paper reviews the role of Vav1 in T cells and the occurrence of related diseases. Key words: T-lymphocytes/physiology Guanine nucleotide exchange factors/physiology Autoimmune diseases Graft rejection Lymphoma, T-cell Review