猪流行性腹泻病毒血清学及临床诊断方法研究进展

猪流行性腹泻病毒（porcine epidemic diarrhea virus, PEDV）是急性、高度传染性猪流行性腹泻（porcine epidemic diarrhea, PED）的致病原，可感染所有日龄的猪，并在哺乳仔猪中引起较高的死亡率。当前使用的疫苗难以对感染仔猪提供有效保护。因此，研制高效安全的PEDV疫苗是防控PED的关键。同时，建立敏感有效的血清学检测方法对于PEDV感染的临床诊断以及免疫后体液免疫应答水平的监测与评估至关重要。本文对当前主要的PEDV血清学研究结果进行概述，并对感染或免疫后抗体消长规律进行讨论，以期为PEDV的诊断与防控提供参考。 通讯作者: 黄耀伟（https://orcid.org/0000-0001-9755-8411） E-mail: yhuang@zju.edu.cn
Abstract: Porcine epidemic diarrhea virus (PEDV) is a causative agent of acute, highly contagious porcine epidemic diarrhea (PED). It infects pigs of all ages and results in high mortality rates particularly in suckling piglets. Current vaccines can not provide efficient protection to infected piglets. Thus, developing safer and more efficacious vaccines is fundamental to the control of PEDV. Meanwhile, it is of significance in establishing sensitive and efficient serological assays for clinical diagnosis of PEDV infection as well as the surveillance and evaluation of humoral responses at post-vaccination. In this review, we summarized the current serological assays and discussed the antibody kinetics at post-infection or vaccination, aiming to provide references to the diagnoses and control of PEDV. Key words: porcine epidemic diarrhea virus (PEDV) serology clinical diagnostic assays vaccine