钛合金表面羟基磷灰石膜及组织相容性

在乙酸钙、磷酸二氢钙为主成分的弱酸性电解液中，以乙二胺四乙酸(EDTA)和柠檬酸作为络合剂，采用微弧氧化的方法，在钛合金表面成功地直接制备出含有羟基磷灰石(HA)的陶瓷层.随着电解液Ca/P的增加，膜层中HA含量升高，膜层表面孔洞分布更均匀，表面变粗糙.动物种植试验表明，陶瓷层覆盖植入体产生的炎症反应较弱，新的肌肉组织能够在膜层表面生长.
By using ethylene diaminetetraacetic acid (EDTA) and citric acid as the complexants, hydroxyapatite (HA) coatings were fabricated by means of one-step micro-arc oxidation (MAO) in the acid electrolytes containing Ca2+ and P5+ions. With the increase of Ca/P in the electrolytes, the content of HA in the coatings obviously increased and the coatings possessed coarser surfaces with fine and well-distributed pores. The results of animal experiments have indicated that the inflammatory reactions induced by implant buttons with HA coatings were minor and the new musculature could grow on the surfaces of the coatings.