阿魏酸酰胺类化合物的合成与表征

阿魏酸及其酰胺类化合物是一类具有重要生物活性和药理作用的天然产物及其衍生物.本论文以廉价易得的香兰素为原料,经克脑文盖尔(Knoevenagel)缩合反应得到阿魏酸(1).然后以N,N′-二环己基碳酰亚胺(DCC)为脱水剂,4-二甲氨基吡啶(DMAP)为催化剂,阿魏酸分别与8种芳香胺反应合成了8种阿魏酸酰胺类化合物2-9.其中7和8是未见文献报道的新化合物.所合成的阿魏酸酰胺类化合物通过核磁共振氢谱(1H NMR)、核磁共振碳谱(13C NMR)、质谱(MS)和红外光谱(IR) 进行了结构表征.该阿魏酸酰胺类化合物合成方法原料易得、工艺简便、收率较高.
Ferulic acid and ferulamides are a class of natural products and derivatives with important biological activity and pharmacological effect. Ferulic acid (1) was synthesized from vanillin through Knoevenagel reaction. Then, a series of ferulamides (2-9) were synthesized through reaction of ferulic acid with amines using DCC as dehydrating agent and DMAP as the catalyst. Compounds 7 and 8 are new compounds. The structures of all synthetic compounds were characterized by NMR、MS and IR spectra. This synthetic method has the advantages of easy availability of starting materials, simple operation and high yield.